Registration Dossier
Registration Dossier
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EC number: 203-453-4 | CAS number: 107-02-8
Toxic effects on livestock and pets
Administrative data
Description of key information
“Based on metabolism studies of acrolein in lactating goats and laying hens, the qualitative nature of the residue in ruminants and poultry is adequately understood. Acrolein was not found in any tissue sample in either study. Major metabolites (>3%) in milk and tissue from the goat study included glucose, glycogen, and lactic acid, aspartate, glutamate, alanine, glycine/serine, and glycerol. Major metabolites identified in the hen study included glycine, glutamate, alanine, oleic acid, stearic acid, glycerol, creatine, cholesterol, aspartate, ornithine, and lactic acid. Other amino acids and fatty acids were identified but were present at lower concentrations in both studies.” quotation from United States Environmental Protection Agency HED Risk Assessment for Reregistration Eligibility Decision (RED) (US EPA 2008)
Additional information
Acrolein has been the subject of a risk assessment carried out under Community Regulation (EEC) No 793/93 (EU, 2001. However, Toxic Effects on Livestock and Pets is no specific chapter in the EU Risk Assessment. The key information on toxic effects of acrolein on livestock an pets as stated is a quotations taken from a further assessments carried out under other international and national programmes published after finalisation of the EU Risk Assessment Report 2001 (United States Environmental Protection
HED Risk Assessment for Reregistration Eligibility Decision (RED) Document for Acrolein (US-EPA, 2008):
1. European Union Risk Assessment Report of Acrolein (EU, 2001)
There is no specific chapter on toxic effects on livestock and pets in the EU Risk assessment.
2. Agreement with further International Reports and Studies Published after Finalisation of the EU Risk Assessment Report 2001
Not applicable.
3. Substantial Disagreements in Comparison to further International Reports to European Union Risk Assessment Report 2001
Not applicable.
4. Additional Aspects in further International Reports
Acrolein is used as pesticide (an aquatic herbicide and biocide) in the . In the recently (March 25, 2008) released document: HED Risk Assessment for Reregistration Eligibility Decision (RED) Document for Acrolein (US-EPA, 2008) some information on Metabolism in livestock and poultry is included: “Based on metabolism studies of acrolein in lactating goats and laying hens, the qualitative nature of the residue in ruminants and poultry is adequately understood. Acrolein was not found in any tissue sample in either study. Major metabolites (>3%) in milk and tissue from the goat study included glucose, glycogen, and lactic acid, aspartate, glutamate, alanine, glycine/serine, and glycerol. Major metabolites identified in the hen study included glycine, glutamate, alanine, oleic acid, stearic acid, glycerol, creatine, cholesterol, aspartate, ornithine, and lactic acid. Other amino acids and fatty acids were identified but were present at lower concentrations in both studies.” EPA, 2008, p19
5. Additional Information in Newer Studies, not Included in the European Union Risk Assessment Report 2001 or further Cited International Reports
None.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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