Registration Dossier
Registration Dossier
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EC number: 203-453-4 | CAS number: 107-02-8
Endpoint summary
Administrative data
Description of key information
Additional information
On the basis of the high water solubility and chemical reactivity of acrolein and its low experimentally determined log Kow of -1.10, no bioaccumulation would be expected.
This is confirmed by a study with Bluegill sunfish exposed to 14C-acrolein for 28 days. Although the half life for removal of the radiolabelled acrolein was more than 7 days indicating a BCF of 344, this does not indicate the bioaccumulation of acrolein per se, but rather rather incorporation of the radioactive carbon into tissues following the reaction of acrolein with protein sulfhydryl groups or metabolism of absorbed acrolein and incorporation of label into intermediary metabolites.
Similar results are obtained by two studies with plants (Capsium sp. and Lactuca sativa) exposed to acrolein. Rapid reduction of the acrolein concentrations in plant tissue were observed for Capsium sp.. A half-life of 10.3 hours in the tissue of pepper plants was determined. Furthermore in the study with Lactuca sativa exposed to 14C-acrolein very rapid degradation of 14C-acrolienb was observed. Acid-hydrolysable metabolic products, although not identified, were detected, suggesting multiple, conjugated polar metabolites of 14C-acrolein or biological components which have incorporated 14C-fragments resulting from further degradation of 14C-acrolein metabolites.
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