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Diss Factsheets
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EC number: 242-367-1 | CAS number: 18480-07-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Strontium substances have been tested in bacterial reverse mutation assays, in vitro gene mutation and chromosome aberration test.
- in-vitro gene mutation in bacteria (OECD 471): negative (no data is available for Sr(OH)2, thus read-across from SrCl2 to Sr(OH)2 was performed)
- in-vitro gene mutation in mammalian cells (OECD 476): negative (no data is available for Sr(OH)2, thus read-across from Sr(NO3)2 to Sr(OH)2 was performed)
- in-vitro chromosome aberration (OECD 473): negative (no data is available for Sr(OH)2, thus read-across from Sr(NO3)2 to Sr(OH)2 was performed)
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
- Mutagenicity, in vitro gene mutation study in bacteria
- Mutagenicity, in vitro cytogenicity study in mammalian cells or in vitro micronucleus study
- Mutagenicity, in vitro gene mutation study in mammalian cells
No genotoxicity study is available on Strontium hydroxide itself. However, an analogue approach is used for the read-across of genotoxicity properties of strontium hydroxide from strontium chloride or strontium nitrate, based on the hypothesis that properties are likely to be similar as a result of the presence of a common metal ion Sr2+. Further information on the read-across justification is included as attachment in Section 13.
The analogue approach was applied to the following endpoints:
It is concluded that strontium nitrate did not induce micronuclei in cultured human peripheral blood lymphocytes following treatments in the absence and presence of an Aroclor induced rat liver metabolic activation system (S-9 mix). Based on read-across the same is considered true for strontium hydroxide. Concentrations were tested and analysed up to 2116 µg/mL.
It is concluded that strontium nitrate did not induce mutation at the tk locus of L5178Y mouse lymphoma cells when tested under the conditions employed in this study . Based on read-across the same is considered true for strontium hydroxide.
These conditions included treatments up to precipitating concentrations in two independent experiments, in the absence and presence of a rat liver metabolic activation system (S-9 mix).
Further testing of in vivo genetic toxicity tests is not considered necessary.
Justification for classification or non-classification
Based on the read-across approach from strontium chloride or strontium nitrate, Strontium hydroxide is not expected to have mutagenicity / genotoxicity potential and no classification and labelling is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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