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Toxicological information

Toxicity to reproduction: other studies

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Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: publication does not give sufficient experimental details

Data source

Reference
Reference Type:
publication
Title:
Testing of selected workplace chemicals for teratogenic potential
Author:
Hardin, B., D.; et al.
Year:
1981
Bibliographic source:
Scand j work environm. health 7, suppl. 4, 66-75

Materials and methods

Principles of method if other than guideline:
other: developmental toxicity study
GLP compliance:
no
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzothiazole-2-thiol
EC Number:
205-736-8
EC Name:
Benzothiazole-2-thiol
Cas Number:
149-30-4
Molecular formula:
C7H5NS2
IUPAC Name:
1,3-benzothiazole-2-thiol
Details on test material:
MBT

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
corn oil
Duration of treatment / exposure:
day 1 to day 15 of gestation
Frequency of treatment:
daily
Duration of test:
up to day 21 of gestation
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 200 mg/kg bw
Basis:

Control animals:
yes

Results and discussion

Any other information on results incl. tables

MBT administration: treatment-related effects were limited to evidence of maternal or fetal toxicity. No adverse effects on fetal development were indicated.

Applicant's summary and conclusion