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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only secondary literature available

Data source

Referenceopen allclose all

Reference Type:
other: cited in BG Chemie 2000
Title:
Toxicity of a rubber accelerator
Author:
Guess, W., L.; et al.
Year:
1969
Bibliographic source:
Toxicol. Appl. Pharmacol., 14, 221-231
Reference Type:
publication
Title:
Toxikologische Bewertung 2-Mercaptobenzothiazol, Nr. 70, CAS Nr. 149-30-4
Author:
BG Chemie
Year:
2000
Bibliographic source:
Berufsgenossenschaft der chemischen Industrie, ISSN 0937-4248

Materials and methods

Principles of method if other than guideline:
other: subacute toxicity study

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzothiazole-2-thiol
EC Number:
205-736-8
EC Name:
Benzothiazole-2-thiol
Cas Number:
149-30-4
Molecular formula:
C7H5NS2
IUPAC Name:
1,3-benzothiazole-2-thiol
Details on test material:
MBT

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
1 week
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 55, 110 mg/kg bw
No. of animals per sex per dose:
10 per dose
Control animals:
yes

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Gross pathology: no effects

Effects on the liver and kidney, no effects on lung, heart, testis and thyroid gland

hexobarbital-induced sleeping phase extended

Applicant's summary and conclusion