Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: publication does not give sufficient experimental details

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicity of sulphenamide derivatives of MBT used as vulcanisation accelerators
Author:
Vorobeva, R., S. et al.
Year:
1962
Bibliographic source:
Soviet Rubber Technology 21, no. 6, 14-15
Reference Type:
publication
Title:
An experimental study of comparative toxicity proper to new vulcanization accelerating agents (BTMA, Santocure, Santocure-Mor)
Author:
Vorobeva, R., S.; et al.
Year:
1962
Bibliographic source:
Gigiena Truda i Prof. Zabol. 6(7), 28-33

Materials and methods

Principles of method if other than guideline:
other: subacute inhalation study
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzothiazole-2-thiol
EC Number:
205-736-8
EC Name:
Benzothiazole-2-thiol
Cas Number:
149-30-4
Molecular formula:
C7H5NS2
IUPAC Name:
1,3-benzothiazole-2-thiol
Details on test material:
MBT

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation: dust
Duration of treatment / exposure:
2 h per day for 15 days
Doses / concentrations
Remarks:
Doses / Concentrations:
300 to 400 mg/m3
Basis:

Results and discussion

Effect levels

Dose descriptor:
LOAEC
Effect level:
300 - 400 mg/m³ air
Basis for effect level:
other: body weight reduction

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Body weight reduced

Clinical signs: unbalancing

No increase of oxygen-consumption, no evidence on effects on the nervous system

histology: macroscopic no effects, histologic effects on the alveolar septum

Applicant's summary and conclusion