Registration Dossier
Registration Dossier
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EC number: 205-736-8 | CAS number: 149-30-4
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: publication does not give sufficient experimental details
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicity of sulphenamide derivatives of MBT used as vulcanisation accelerators
- Author:
- Vorobeva, R., S. et al.
- Year:
- 1 962
- Bibliographic source:
- Soviet Rubber Technology 21, no. 6, 14-15
- Reference Type:
- publication
- Title:
- An experimental study of comparative toxicity proper to new vulcanization accelerating agents (BTMA, Santocure, Santocure-Mor)
- Author:
- Vorobeva, R., S.; et al.
- Year:
- 1 962
- Bibliographic source:
- Gigiena Truda i Prof. Zabol. 6(7), 28-33
Materials and methods
- Principles of method if other than guideline:
- other: subacute inhalation study
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzothiazole-2-thiol
- EC Number:
- 205-736-8
- EC Name:
- Benzothiazole-2-thiol
- Cas Number:
- 149-30-4
- Molecular formula:
- C7H5NS2
- IUPAC Name:
- 1,3-benzothiazole-2-thiol
- Details on test material:
- MBT
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation: dust
- Duration of treatment / exposure:
- 2 h per day for 15 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
300 to 400 mg/m3
Basis:
Results and discussion
Effect levels
- Dose descriptor:
- LOAEC
- Effect level:
- 300 - 400 mg/m³ air
- Basis for effect level:
- other: body weight reduction
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Body weight reduced
Clinical signs: unbalancing
No increase of oxygen-consumption, no evidence on effects on the nervous system
histology: macroscopic no effects, histologic effects on the alveolar septum
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
