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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
other: microfiche
Title:
Unnamed
Year:
1977

Materials and methods

Principles of method if other than guideline:
other: acute toxicity study
GLP compliance:
no
Test type:
other: acute toxicity study

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzothiazole-2-thiol
EC Number:
205-736-8
EC Name:
Benzothiazole-2-thiol
Cas Number:
149-30-4
Molecular formula:
C7H5NS2
IUPAC Name:
1,3-benzothiazole-2-thiol
Details on test material:
2-mercaptobenzothiazole Dry Strain: batch 48/6/1001/0

Test animals

Species:
rat
Strain:
other: Charles River rats
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Duration of exposure:
4 h
Concentrations:
1270 mg/m3
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 1 270 mg/L air

Any other information on results incl. tables

Mortality: 0/5

Clinical symptoms: Ptosis and hypoactivity were observed after 90 minutes of exposure and lasted 55 minutes. No deaths were observed during exposure or the 14 day observation period which followed.

The average 2 -week body weight gain were within the normal limits.

Pathology: complete necropsies were done on all male and female rats used in this experiment when study was terminated at the end of the 14 -day post-exposure observation period. No gross tissue changes attributable to the effects of the test material were observed in any of the rats examined.

Particle size distribution:

A sample of airborn dust was collected from the test atmosphere for purpose of conducting a microscopic determination of particle size distribution. Particles were counted with respect to 4 size ranges, viz. 5 mircron or smaller, 6 to 10 micron, 11 to 25 microns and larger than 25 microns.

 Particle Size range(microns)  Number of particles counted  Percent of total counted
 1 -5  165  78.2
 6 -10  22  10.4
 11 -25  16  7.6
 < 25  8  3.8

Applicant's summary and conclusion