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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1975
Reference Type:
publication
Title:
Acute toxicologic evaluation of mercaptobenzothiazole
Author:
Randall, D., J.; et al.
Year:
1990
Bibliographic source:
Journal of American College of Toxicology, part B, vol.1, 62

Materials and methods

Principles of method if other than guideline:
other: acute oral toxicity study
GLP compliance:
no
Test type:
other: acute oral toxicity study
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzothiazole-2-thiol
EC Number:
205-736-8
EC Name:
Benzothiazole-2-thiol
Cas Number:
149-30-4
Molecular formula:
C7H5NS2
IUPAC Name:
1,3-benzothiazole-2-thiol
Details on test material:
mercaptobenzothiazole (MBT) THIOTAX powder, purity: 97.4 %

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
3160, 3980, 5010, 6310 mg/kg bw
No. of animals per sex per dose:
5 (males and females mixed)
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 800 mg/kg bw
Based on:
test mat.
95% CL:
3 530 - 4 100
Remarks on result:
other: Clinical signs: reduced appetite and activity, increased weakness, collapse and death.

Any other information on results incl. tables

Mortality:

3160 mg/kg bw: 0/3 males, 0/2 females, combined: 0/5

3980 mg/kg bw: 0/2 males, 3/3 females, combined: 3/5

5010 mg/kg bw: 3/3 males, 2/2 females, combined: 5/5

6310 mg/kg bw: 2/2 males, 3/3 females, combined: 5/5

Time of mortality: one to three days

The calculated oral LD50 for MBT was 3800 mg/kg (95% confidence limits 3530 - 4100 mg/kg bw). For the doses of 3160, 3980, 5010 and 6310 mg/kg, the number of deaths were 0, 3, 5 and 5, respectivly, out of 5 animals per group. Clinical signs included reduced appetite and activity (1 to 3 days in survivors), increasing weakness, collapse and death. Autopsy of decedents showed lung hypermia, slight liver discoloration, and gastrointestinal inflammation. Viscera of surviving animals appeared normal at sacrifice.

Applicant's summary and conclusion