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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
The identification of contact allergens by human assay
Author:
Kligman, A., M.
Year:
1966
Bibliographic source:
The Journal of Investigative Dermatology, vo. 47, no. 5, 393-409

Materials and methods

Type of sensitisation studied:
skin
Study type:
study with volunteers
Principles of method if other than guideline:
other: maximization assay
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzothiazole-2-thiol
EC Number:
205-736-8
EC Name:
Benzothiazole-2-thiol
Cas Number:
149-30-4
Molecular formula:
C7H5NS2
IUPAC Name:
1,3-benzothiazole-2-thiol
Details on test material:
MBT

Method

Type of population:
general
Route of administration:
dermal

Results and discussion

Results of examinations:
9/24 voluntees showed allergic skin reactions

Applicant's summary and conclusion