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Toxicological information

Epidemiological data

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Administrative data

Endpoint:
epidemiological data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable, well-documented publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Cancer risk in chemical production workers exposed to 2-mercaptobenzothiazole
Author:
Sorahan, T.
Year:
2009
Bibliographic source:
Occup. Environ. Med. 66, 269-273

Materials and methods

Study type:
cohort study (retrospective)
Endpoint addressed:
carcinogenicity
Principles of method if other than guideline:
other: investigation of cancer risk in chemical production workers
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzothiazole-2-thiol
EC Number:
205-736-8
EC Name:
Benzothiazole-2-thiol
Cas Number:
149-30-4
Molecular formula:
C7H5NS2
IUPAC Name:
1,3-benzothiazole-2-thiol
Details on test material:
2-mercaptobenzothiazole

Method

Details on study design:
The mortality (1955 to 2005) and cancer morbidity experience (1971 to 2005) of a cohort of 363 male production workers exposed to MBT while employed at a chemical in north Wales were investigated. Two analytical approaches were used, indirect standardisation and Poisson regression.
Exposure assessment:
estimated

Results and discussion

Results:
Limited findings

Any other information on results incl. tables

Based on national mortality rates, significant excess mortality was found for cancers of the large intestine and bladder. Non-significant excesses were shown for lung cancer and multiple myeloma. Based on national cancer incidence rates, significant excess morbidity was found for cancer of the bladder and multiple myeloma. Non-significant excesses were shown for cancers of the large intestine and lung. In analyses that included follow-up information on an additional 1797 plant employees not exposed to MBT, Poisson regression showed significant positive trends both for risks of cancer of the large intestine and for risks of multiple myeloma in relation to estimated cumulative exposure to MBT. The authors concluded that MBT may be a human carcinogen.

Applicant's summary and conclusion