Registration Dossier

Toxicological information

Specific investigations: other studies

Currently viewing:

Administrative data

Endpoint:
specific investigations: other studies
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable well-documented publication, which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Studies of the reactivity of morpholine, 2-mercaptobenzothiazole and 2 of their derivates with amino acids
Author:
Wang, X.; et al.
Year:
1988
Bibliographic source:
Contact Dermatitis 19, 16-21

Materials and methods

Principles of method if other than guideline:
in vitro assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzothiazole-2-thiol
EC Number:
205-736-8
EC Name:
Benzothiazole-2-thiol
Cas Number:
149-30-4
Molecular formula:
C7H5NS2
IUPAC Name:
1,3-benzothiazole-2-thiol
Details on test material:
MBT

Results and discussion

Details on results:
compounds with Cys/MBT, Lys/MBT were detected

Any other information on results incl. tables

The -SH group of MBT may react either via oxidation and/or thioester formation with the carboxylate group of amino acids.

Applicant's summary and conclusion