Registration Dossier
Registration Dossier
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EC number: 215-238-2 | CAS number: 1314-61-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The key study was a skin sensitisation study conducted in accordance with OECD guideline 406 using a Magnusson and Kligman test (Török-Bathó, 2013). Tantalum pentoxide was tested negative for skin sensitisation in this study.
In a second sensitisation study tantalum pentoxide was tested for sensitizing properties in accordance with OECD guideline 429 using the mouse Local Lymph Node Assay (Hargitai, 2013). In this study a stimulation index greater than 3 was obtained at the mid-concentration of 25 % but not at 50 % or 10 %. As no dose response occurred tantalum pentoxide can be considered as potentially not sensitizing, but the result from this study need to be verified.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In accordance with criteria for classification for skin sensitisation of Regulation (EC) No. 1272/2008 and Directive 67/548/EEC , the test material did not elicit a response in the Maximisation assay and therefore does not meet the criteria for classification as a skin sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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