Sulfonic acids, C14-17-sec-alkane, sodium salts

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1975

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study was conducted according to accepted scientific standards at time of performance. Sufficiently documented and reported.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Repeated dermal application of test material

GLP compliance:

no

Test type:

other: dermal application

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sulfonic acids, C14-17-sec-alkane, sodium salts

EC Number:

307-055-2

EC Name:

Sulfonic acids, C14-17-sec-alkane, sodium salts

Cas Number:

97489-15-1

Molecular formula:

H3C-(CH2)m-CH-(SO3Na)-(CH2)n-CH3

IUPAC Name:

Sulfonic acids, C14-17-sec-alkane, sodium salts

Constituent 2

Reference substance name:

Hostapur SAS 60

IUPAC Name:

Hostapur SAS 60

Details on test material:

- Name of test material (as cited in study report): Hostapur SAS 60

- Physical state: pasty
- Analytical purity: 60%
- Composition of test material, percentage of components: 60% Hostapur SAS 93, water
- Isomers composition: n.a.
- Purity test date: 1974-09-03
- Lot/batch No.: no data
- Expiration date of the lot/batch: 1976-10-01
- Radiochemical purity (if radiolabelling): n.a.
- Specific activity (if radiolabelling): n.a.
- Locations of the label (if radiolabelling): n.a.
- Expiration date of radiochemical substance (if radiolabelling): n.a.
- Stability under test conditions: stability and homogeneity guaranteed
- Storage condition of test material: in darkness at room temperature
- Other:

Test animals

Species:

mouse

Strain:

CD-1

Sex:

female

Details on test animals or test system and environmental conditions:

see section 7.5.2 Repeated dose toxicity: dermal

Administration / exposure

Type of coverage:

open

Vehicle:

water

Details on dermal exposure:

see section 7.5.2 Repeated dose toxicity: dermal

Duration of exposure:

see section 7.5.2 Repeated dose toxicity: dermal

Doses:

0.1 mL of up to 32% (w/v) per mouse per day

No. of animals per sex per dose:

25

Control animals:

yes

Details on study design:

see section 7.5.2 Repeated dose toxicity: dermal

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

approximate LD50

Effect level:

> 2 000 mg/kg bw

Remarks on result:

other: calculated

Mortality:

No mortality

Clinical signs:

other: see section 7.5.2 Repeated dose toxicity: dermal

Gross pathology:

see section 7.5.2 Repeated dose toxicity: dermal

Other findings:

see section 7.5.2 Repeated dose toxicity: dermal

Any other information on results incl. tables

see section 7.5.2 Repeated dose toxicity: dermal

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Repeated dermal application on mice of test material solutions as high as 32 % (w/v), 5 days per week for 4 weeks resulted neither in mortality nor
substance related systemic toxicity. The acute dermal toxicity of the test material is therefore calculated to be gretaer 2000 mg/kg body weight.

Executive summary:

see section 7.5.2 Repeated dose toxicity: dermal