Registration Dossier
Registration Dossier
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EC number: 307-055-2 | CAS number: 97489-15-1
Endpoint summary
Administrative data
Description of key information
The acute oral toxicity of sec-alkane sulfonate-sodium salts SAS (93%) was investigated in male and female rats using OECD test guideline 401. The study followed the principles of GLP and is regarded to be valid without restrictions. After administration of 2000 mg/kg body weight all animals died whereas after application of 500 mg/kg body weight no mortalities occurred. The LD50 after oral application is between 500 and 2000 mg/kg body weight. Regarding dermal exposure, all available data do not indicate any acute and/or systemic toxic potential of sec-alkane sulfonate-sodium sal SAS (93%). No data are available to evaluate the acute inhalation toxicity of sec-alkane sulfonate-sodium salts SAS (93%) but due to the physical chemical characteristics inhalation is no exposure route of concern.
Key value for chemical safety assessment
Additional information
The acute oral toxicity (LD50) of sec-alkane sulfonate-sodium salts SAS in rats and mice are reflecting the different grades tested in a concentration dependent manner. The acute median lethal dose of technical grade sec-alkane sulfonate SAS at 93% is between 500 and 2000 mg/kg body weight whereas sec-alkane sulfonate-sodium salts SAS tested at lower concentrations (e.g. 60%, 30%) revealed LD50 values above 2000 mg/kg body weight. Based on all available studies no indications of special target organs and/or specific toxic effects were revealed. Regarding acute systemic dermal toxicity, all available data do not indicate any toxic potential of concern. Data on inhalation toxicity do not exist. However, due to the chemical nature and physical form of sec-alkane sulfonate-sodium salts SAS inhalation is no exposure route of concern.
Justification for classification or non-classification
Technical grade sec-alkane sulfonate-sodium salts SAS at 93% has to be classified as harmful with regard to acute oral toxicity based on the results obtained. No classification is deducible for lower concentrated aqueous sec-alkane sulfonate-sodium salts SAS as well as for the endpoint acute dermal systemic toxicity as the available acute dermal LD50 is above 2000 mg/kg body weight.
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