Registration Dossier
Registration Dossier
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EC number: 265-191-7 | CAS number: 64742-88-7 A complex combination of hydrocarbons obtained from the distillation of crude oil or natural gasoline. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C9 through C12 and boiling in the range of approximately 140°C to 220°C (284°F to 428°F).
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
In the key dermal photoirritation study, the irritation index is 4.8 for Jet fuel A-1 exposed to UV A light and 4.1 for Jet fuel A-1 not exposed to UV A light. Therefore, the photoirritation index is 0.7 and the test substance is not considered a photoirritant.
Additional information
In a key dermal photoirritation study (Klimisch score=1; ARCO, 1992y), five female New Zealand White rabbits were exposed to 0.3 mL of undiluted thermocracked kerosine on two intact areas of the skin for one hour. Concurrent positive and untreated controls were also applied to two intact areas. After test article or positive control exposure, half of the sites were exposed to UV A light for 5.9 hours and were observed 30 minutes, 24, 48, and 72 hours after UV A exposure. Irritation and photoirritation were scored using the Draize scoring method. The positive control induced an appropriate response with a photoirritation index of 4.4 and is considered a moderate photoirritant. The photoirritation index for thermocracked kerosine is 1.5 and is therefore considered to be a slight photoirritant, under the conditions of this study.
In 3 supporting photoirritation studies (ARCO, 1992z; ARCO 1992aa; ARCO 1991b) , undiluted straight run kerosine and Jet fuel A-1 was applied to two sites on the shorn skin of each of 5 female rabbits. A 1% solution (0.3 mL) of 8-methoxypsoralen (MOP) was applied to two different sites on each of the rabbits. Two sites received no test material and these served as negative control sites. One hour after application of test material or MOP, wrappings were removed and any residual test or positive control material was wiped from the skin. One each of the test sites, positive control sites and negative control sites were then covered with a light-impervious material and he animals were then exposed to 10J/cm² of UV A light for 5.9 hours. After the exposure to UV A, sites were examined for responses 30 minutes, 24, 48 and 72 hours. Skin responses were evaluated and scored using the Draize scale.
In the first study, the irritation index was 4.2 for straight run kerosine exposed to UVA and 4.3 for straight run kerosine not exposed to UVA; therefore, the photoirritation index is -0.1. Under the conditions of this study the test material is considered a non-irritant. In the second study, the irritation index is 4.7 for straight run kerosine exposed to UVA and 3.7 for straight run kerosine not exposed to UVA ; therefore, the photoirritation index is 1.0. Under the conditions of this study, the test article is classified as a slight photoirritant. The irritation index is 4.8 for Jet fuel A-1 exposed to UV A light and 4.1 for Jet fuel A-1 not exposed to UV A light. Therefore, the photoirritation index is 0.7 and the test substance is not considered a photoirritant.
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