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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972

Materials and methods

Principles of method if other than guideline:
Acute oral toxicity study in male rats.
GLP compliance:
not specified
Test type:
other: Acute oral toxicity in rats
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
technically pure 3-chloro-p-toluidine, dissolved in polyethylene glycol

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Lutrol
Doses:
100, 250, 500, 950, 1000, 1100, 1150, 1300 mg/kg bw.
No. of animals per sex per dose:
15
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
1 053 mg/kg bw

Any other information on results incl. tables

Results:

 Dose (mg/kg bw)  Toxicological result after 14 days        Signs of intoxications     Timepoint of death after days
   Nr. of death animals  Nr. of animals with symptoms  Nr. of animals used  Start Endpoint   
  100  0  0  15  -  -  -
  250  0  15  15  30 min  4 days  -
  500  0  15  15  15 min  7 days  -
  950  3  15  15  10 min  7 days  1 day
 1000  3  15  15  8 min  7 days  1 -2 days
 1100  9  15  15  6 min  7 days  1 -2 days
 1150  13  15  15  5 min  7 days  1 -2 days
 1300 days  15  15  15  4 min  -  1 day

The animals showed cyanosis, labored breathing, sedative effects and a clearly diminuated general condition after 30 min after the oral application. The signs of intoxication could be observed 4 -7 days. The timepoint of death occurred within 48 hours.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The LD 50 was 1053 mg/kg bw.
Executive summary:

In an acute oral toxicity test in male Wister rats the animals were administered by gavage with the test substance dissolved in Lutrol.

The doses tested were: 100, 250, 500, 950, 1000, 1100, 1150, 1300 mg/kg bw.

The animals showed cyanosis, labored breathing, sedative effects and a clearly diminuated general condition after 30 min after the oral application. The signs of intoxication could be observed 4 -7 days. The timepoint of death occurred within 48 hours.

The LD 50 was 1053 mg/kg bw.