Registration Dossier

Administrative data

Description of key information

Valeryl chloride was found to be highly corrosive to the rabbit skin under semiocclusive conditions. Dermal application for 3 minutes and 1 hour caused full thickness necrosis.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Skin irritation

Valeryl chloride was applied to the skin of one New Zealand White rabbit for 3 minutes and 1 hour under semiocclusive conditions in a GLP compliant OECD guideline 404 study (BASF AG, 1997). Full thickness necrosis was observed at 1 and 24 hour after patch removal at both exposure durations and erythema and edema (scores of 2 and 3) were observed beyond the area of exposure. Therefore, the study was terminated after 24 hours. Valeryl chloride was judged highly corrosive to the skin.

 

Eye irritation

In accordance with column 2 of REACH Annex VII, no testing on eye irritation is necessary as the substance is classified as corrosive to the skin according to Directive 67/548/EEC (C, R35) and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 (H314, Category 1A).


Effects on skin irritation/corrosion: highly corrosive

Effects on eye irritation: highly corrosive

Justification for classification or non-classification

Based on the available data, valeryl chloride needs to be classified according to Directive 67/548/EEC (C, R35) and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 (Category 1A, H314).