Registration Dossier
Registration Dossier
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EC number: 211-330-1 | CAS number: 638-29-9
Endpoint summary
Administrative data
Description of key information
The LC50 for valeryl chloride in rats is 2.07 mg/L.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Inhalation toxicity
In a GLP compliant OECD 403 guideline study in which rats (5/sex/group) were exposed for 4 hours to 0.35, 2.02 and 4.86 mg/L valeryl chloride, no deaths were observed after a 14-day observation period at the lowest exposure level, 3/5 males and 2/5 females died at the medium exposure level and 4/5 males and 5/5 females at the highest exposure level after 14 days (1990). The LC50 value was calculated to be 2.07 mg/L. General congestion in all animals, focal hyperemia with emphysema in the lungs (2.02 mg/L) and focal hyperemia with emphysema and edema in the lungs (4.86 mg/L) were observed in the animals that died during the study. Clinical signs included irregular and accelerated respiration, eyelid closure, eye discharge, restlessness and ruffled fur at all exposure levels; additionally: intermittent respiration, salivation, nasal discharge, nose with smear and crusts, stretched position when breathing, squatting posture and deteriorated general state at the mid and high concentration.
Oral and dermal toxicity
Further studies regarding acute oral and dermal toxicity do not have to be performed: in accordance with column 2 of REACH Annex VIII as the substance is classified as corrosive to the skin according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 (H314, Category 1A).
Justification for classification or non-classification
The available acute inhalation toxicity data warrants classification with Cat. 3; H331 according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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