Registration Dossier
Registration Dossier
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EC number: 211-330-1 | CAS number: 638-29-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound valeryl chloride: No data.
Hydrolysis product valeric acid: Acutely harmful to aquatic invertebrates.
Hydrolysis product HCl: Acutely very toxic for aquatic invertebrates (pH dependent).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 45 mg/L
Additional information
Parent compound valeryl chloride (CAS 638 -29 -9):
No data are available for valeryl chloride (CAS 638 -29 -9). The substance rapidly decomposes in water and forms HCl (CAS 7647 -01 -0) and valeric acid (CAS 109 -52 -4). Therefore, the short-term toxicity to aquatic invertebrates is assessed on the basis of data on valeric acid.
Hydrolysis product valeric acid (CAS 109 -52 -4):
For valeric acid (CAS 109 -52 -4) a study is available to assess the short-term toxicity towards aquatic invertebrates. The 48 -h LC50 determined with the waterflea (Daphnia magna) was 45 mg/L (nominal; OECD SIDS, 2010). In addition, a read-across analysis was performed with QSAR Toolbox v4.4. Based on three nearest neighbours, the 48 -h EC50 was determined to be 65.1 mg/L (BASF SE, 2020). The substance is within the applicability domain of the model.
In conclusion, valeric acid is considered to be acutely harmful to aquatic invertebrates.
Hydrolysis product hydrochloric acid (HCl; CAS 7647 -01 -0):
The hydrolysis product hydrochloric acid (HCl) was tested in a semi-static acute toxicity test according to OECD 202 with Daphnia magna. The 48-h EC50 was 0.492 mg/L (acid equivalent to pH 5.3; OECD SIDS, 2002).
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