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Diss Factsheets

Administrative data

Endpoint:
toxicity to other aquatic vertebrates
Type of information:
experimental study
Remarks:
data for the hydrolysis product valeric acid (CAS 109-52-4)
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1996

Materials and methods

Principles of method if other than guideline:
Calculation of 96-h LC50 (lethality), 96-h EC50 (malformation), and DHI (developmental hazard index = 96-h LC50/96-h EC50) values. The endpoint data were subjected to quantitative structure-activity relationship (QSAR) analyses and computer-automated structure evaluation (CASE).
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Valeric acid
EC Number:
203-677-2
EC Name:
Valeric acid
Cas Number:
109-52-4
IUPAC Name:
valeric acid
Details on test material:
- Name of test material (as cited in study report): pentanoic acid

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
no

Test organisms

Aquatic vertebrate type (other than fish):
frog
Test organisms (species):
Xenopus laevis
Details on test organisms:
Testing was performed using dejellied embryos.

Study design

Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
2 728.5 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 95% Cl (2642 - 2816)
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
206.1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
morphology
Remarks on result:
other: 95% Cl (191-221)

Any other information on results incl. tables

Developmental hazard index: 13.2

Applicant's summary and conclusion