Registration Dossier

Administrative data

Endpoint:
toxicity to other aquatic vertebrates
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1996

Materials and methods

Principles of method if other than guideline:
Calculation of 96-h LC50 (lethality), 96-h EC50 (malformation), and DHI (developmental hazard index = 96-h LC50/96-h EC50) values. The endpoint data were subjected to quantitative structure-activity relationship (QSAR) analyses and computer-automated structure evaluation (CASE).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): pentanoic acid

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Xenopus laevis

Study design

Limit test:
no
Total exposure duration:
96 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
2 728.5 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 95% Cl (2642 - 2816)
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
206.1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
morphology
Remarks on result:
other: 95% Cl (191-221)

Any other information on results incl. tables

Developmental hazard index: 13.2

Applicant's summary and conclusion