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Description of key information

In contact with water valeryl chloride will hydrolyse rapidly.

Key value for chemical safety assessment

Additional information


In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.

According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.

For the assessment of Valeryl chloride (CAS 638-29-9) (Q)SAR results were used for hydrolysis.The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.

Therefore, further experimental studies on hydrolysis are not provided.


No experimental data on the hydrolysis of valeryl chloride are available. HYDROWIN 2.00 data indicate that acyl halides, like valeryl chloride, usually have hydrolytic half-lives of less than 10 minutes (BASF SE, 2020).

Valeryl chloride (CAS 638-29-9) hydrolyses rapidly and forms valeric acid (CAS 109-52-4) and hydrochloric acid (HCl, CAS 7647 -01 -0).