Registration Dossier
Registration Dossier
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EC number: 222-823-6 | CAS number: 3622-84-2
Endpoint summary
Administrative data
Description of key information
1)Assessment of the Bioaccumulation potential for the substance N-butylbenzenesulphoneamide.
There are different criteria for deciding if a substance has indications of bioaccumulation potential. One way to evaluate the potential for bioaccumulation in aquatic species is to measure bioconcentration factor (BCF). Other criteria for assessing of the bioaccumulation are, Log Po/w as high fat solubility signalizes a high probability of a bioaccumulation potential, particularly with respect to storage fat, as well as surface tension. Surface-active substances tend to adsorb to surfaces and to accumulate at phase interfaces. Finally chemicals can be accumulated in organisms by direct uptake e.g. through adsorption onto biological surfaces (skin, gills). An overview of the values for BBSA obtained for the different bioaccumulation criteria are given in table 1.
Tabel 1: BBSA criteria for assessing of the bioaccumulation.
| Criteria | Criteria for being bioaccumulative | Results for BBSA |
| Log Po/w | >3 | 2.01 exp (OECD 117) |
| Surface tension | <50 mN/m | 70.16 mN/m exp (OECD115) |
| Log Kp | >3 | -2.47 (QSAR) |
| BCF | >2000 L/kg | 15 L/kg (QSAR), 3 L/kg (exp) |
None of the listed results for BBSA (table 1) meet the criteria for being bioaccumulative. Furthermore experimental results in cyprinus carpio fish( 3.8 % lipid content) exposed for 6 weeks to BBSA at dose levels of 2 µg/L and 20µg/L revealed very low Bioaccumulation values of respectively 3.6 L/kg and 3.3 L/kg.
Conclusion.
Based on all the available data today it can be concluded that N-butylbenzenesulfonamide cas 3622-84-2 has no bioaccumulation potential.
Additional information
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