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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
5.84 mg/m³
Most sensitive endpoint:
repeated dose toxicity
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
other: "Guidance on Assessment Factors to derive DNEL" (ECETOC Technical Report No. 110, 2010).
Modified dose descriptor starting point:
other:
Value:
5.84 mg/m³
Explanation for the modification of the dose descriptor starting point:
Not applicable
Justification:
OEL value
Justification:
OEL value
Justification:
OEL value
Justification:
OEL value
Justification:
OEL value
Justification:
OEL value
Justification:
OEL value
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
11.7 mg/m³
Most sensitive endpoint:
acute toxicity
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
other: "Guidance on Assessment Factors to derive DNEL" (ECETOC Technical Report No. 110, 2010).
DNEL extrapolated from long term DNEL
Modified dose descriptor starting point:
other: 1 ppm for tripropylamine
Value:
5.84 mg/m³
Explanation for the modification of the dose descriptor starting point:
not applicable
Justification:
long-term OEL was multiplied with a factor of 2 to obtain short-term OEL
Justification:
long-term OEL was multiplied with a factor of 2 to obtain short-term OEL
Justification:
long-term OEL was multiplied with a factor of 2 to obtain short-term OEL
Justification:
long-term OEL was multiplied with a factor of 2 to obtain short-term OEL
Justification:
long-term OEL was multiplied with a factor of 2 to obtain short-term OEL
Justification:
long-term OEL was multiplied with a factor of 2 to obtain short-term OEL

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
5.84 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
DNEL derivation method:
other: "Guidance on Assessment Factors to derive DNEL" (ECETOC Technical Report No. 110, 2010).
Dose descriptor:
other: 1 ppm (OEL)
Justification:
OEL value
Justification:
OEL value
Justification:
OEL value
Justification:
OEL value
Justification:
OEL value
Justification:
OEL value
Justification:
OEL value
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
11.7 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
DNEL derivation method:
other: "Guidance on Assessment Factors to derive DNEL" (ECETOC Technical Report No. 110, 2010).
DNEL extrapolated from long term DNEL
Dose descriptor starting point:
other: 1 ppm fro tripropylamine (5.84 mg/m³)
Justification:
long-term OEL was multiplied with a factor of 2 to obtain short-term OEL
Justification:
long-term OEL was multiplied with a factor of 2 to obtain short-term OEL
Justification:
long-term OEL was multiplied with a factor of 2 to obtain short-term OEL
Justification:
long-term OEL was multiplied with a factor of 2 to obtain short-term OEL
Justification:
long-term OEL was multiplied with a factor of 2 to obtain short-term OEL
Justification:
long-term OEL was multiplied with a factor of 2 to obtain short-term OEL

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.83 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
Route of original study:
Oral
DNEL related information
DNEL derivation method:
other: "Guidance on Assessment Factors to derive DNEL" (ECETOC Technical Report No. 110, 2010).
Modified dose descriptor starting point:
NOAEL
Value:
40 mg/kg bw/day
Explanation for the modification of the dose descriptor starting point:
No dermal repeated dose toxicity study is available for tripropylamine. Therefore, an oral combined repeated dose toxicity study in rats for trimethylamine is taken for DNEL derivation.
Justification:
clear dose response
Justification:
sub-chronic study
Justification:
default for rats
Justification:
default for remaining interspecies differences (covered by total allometry)
Justification:
default for workers
Justification:
read-across data
Justification:
No other uncertainties are identified
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
5.97 mg/kg bw/day
Most sensitive endpoint:
acute toxicity
Route of original study:
Dermal
DNEL related information
DNEL derivation method:
other: "Guidance on Assessment Factors to derive DNEL" (ECETOC Technical Report No. 110, 2010).
Modified dose descriptor starting point:
other: LD50
Value:
430 mg/kg bw/day
Explanation for the modification of the dose descriptor starting point:
Not applicable. Dermal study and dermal route of exposure in humans.
Justification:
no information about dose response
Justification:
extrapolation from LD50 to a non-lethal level in animals (rabbits)
Justification:
default for remaining interspecies differences (covered by total allometry)
Justification:
extrapolation from LD50 to a non-lethal level in humans
Justification:
study conducted with the target substance
Justification:
No other uncertainties are identified

Local effects

Long term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
high hazard (no threshold derived)

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

The calculation of the DNELs is performed in accordance with the principles given in ECHA (2008) “Guidance of Information Requirements and Chemical Safety Assessment, Chapter R.8: Characterisation of dose [concentration]-response for human health”. Assessment factors for DNEL derivations are based on "Guidance on Assessment Factors to derive DNEL" (ECETOC Technical Report No. 110, 2012).

Available dose descriptors:

For tri-n-propylamine, the following dose descriptors are available:

Hazard via inhalation route

Long-term exposure – systemic effects:

NOAEL of 247 ppm for systemic effects established in a repeated (sub-chronic) dose toxicity study in rats for the nearest analogue TEA (Lynch et al., 1990) is taken for the DNEL derivation for tripropylamine. The concentration of 247 ppm corresponds to 1444.4 mg/m³ for tripropylamine.

Acute short-term exposure – systemic effects:

According to the 4 -hour LC50 of 1.13 mg/L (obtained by conversion of 1 -hour LC50 of 4.5 mg/L using a factor of 4 for dusts and mists) established in the key acute inhalation study in rats (Biosearch, 1975), tripropylamine is classified as harmful if inhaled (H331) and therefore a DNEL for short-term exposures should be derived. In a following up acute inhalation study, the rats exhibited huddling during 1 -hour exposure to 1.99 mg/L, but no deaths or poor health condition were noted (Biosearch, 1976). Therefore, this exposure level (the lowest tested) is considered to be a LOAEC for acute systemic and local effects.

Long-term exposure - local effects

Tripropylamine is irritating to respiratory tract and the NOAEL of 247 ppm established for its nearest analogue TEA for systemic effects is simultaneously a LOAEC for local effects and irritation. Since irritation is a primary effect, the DNEL for local effects must not be higher than the DNEL for systemic effects.

Acute short-term exposure – local effects:

Similarly to the situation with long-term exposure by inhalation, acute local effects should be sufficiently covered by the DNEL for acute systemic effects. The concentration of 1.99 mg/L is considered to be a LOAEC established in the following-up acute inhalation study in rats. No deaths or remarkable signs of toxicity were noted in exposed animals.

Hazard via dermal route

Long-term exposure – systemic effects:

NOAEL of 40 mg/kg bw for systemic toxicity established in an oral combined repeated dose toxicity study in rats for the nearest analogue TMA (Takashima et al., 2003) is taken for the DNEL derivation for tripropylamine. The starting point can be obtained by conversion of oral NOAEL into dermal NOAEL (route-to-route extrapolation).

Acute short-term exposure – systemic effects:

According to the LD50 of 430 mg/kg bw established in a dermal study in rats (Smyth et al., 1969), tripropylamine is classified as toxic in contact with skin (H311) and therefore a DNEL for short-term exposures should be derived.

Long-term exposure - local effects

Long-term dermal DNEL for local effects should be sufficiently covered by the long-term dermal DNEL for systemic effects.

Acute short-term exposure – local effects:

There is no dose-response information available in the acute dermal toxicity study in rats (Smyth et al., 1969). LD50 of 430 mg/kg bw is based on mortality and there is no further information about a dose which would not cause dermal irritation. Therefore no DNEL can be derived for acute local effects. A qualitative approach to assessing and controlling the risks should be applied (please implement RMMs).

The DNEL for acute systemic effects should cover sufficiently local effects.

For the other non-threshold endpoints (mutagenicity, eye and skin irritation/corrosion) no DNELs can be derived because no No Observed Effect Level could be established from the relevant studies. The controlling of risk of any hazard relevant for these endpoints should be covered by the long-term DNELs and by the DNELs derived for local effects.

Modification of the starting point:

From all available data for the different human health endpoints it is clear that tripropylamine exerts its effects by a threshold mode of action. Thus, DNELs can be calculated for the different threshold endpoints based on the most relevant dose descriptors per endpoint. DNELs are derived based on the available toxicity data for the target substance, reflecting the routes, the duration and the frequency of exposure.

Bioavailability (absorption)

There is no substance-specific information on absorption by the oral, dermal and inhalation routes available for tripropylamine. The absorption rates are assessed based on the physico-chemical properties of the substance and on the effects observed in the toxicokinetic' studies conducted with the nearest analogues TEA and TBA. TEA was readily absorbed in humans if inhaled (Akesson et al., 1988) and after oral administration (Akesson et al., 1989). TBA was also rapidly adsorbed in rats after oral administration (Jantz et al., 1990). Therefore, 100% absorption is considered for these exposure routes (for detailed information on absorption rates, please refer to section "Toxicokinetics, metabolism and distribution" of this CSR or section 7.1 of IUCLID file). Oral and inhalation absorption in rats and in humans are considered to be the same.

A significant dermal absorption is expected for the substance since molecular weight of 143.27 g/mol, log Pow of 0.9 and water solubility of 444 mg/L point to an extensive absorption through the skin. Moreover, irritating properties of the substance might enhance its dermal uptake. Such a prediction is in agreement with the LD50 of 430 mg/kg bw, which leads to the classification of the substance as toxic in contact with skin. In conclusion, based on this data, 100% of dermal absorption is considered for tripropylamine (TGD, Part I, Appendix VI). Dermal absorption in rats and in humans is assumed to be the same since no information for dermal absorption of the target chemical in humans is available.

Route-to-route extrapolation:

Oral-to-dermal extrapolation is performed to obtain long-term dermal NOAEL for systemic effects.

The following formula was used: corrected dermal NOAEL = oral NOAEL x (ABSoral-rat / ABSderm-human) where ABS is absorption.

Exposure conditions:

The rats were exposed 6 hours to the test substance while workers are exposed 8 hours per day.

6.7 m³ and 10 m³ are standard respiratory volumes for workers under normal conditions and by light activity.

No adjustment in time scaling was performed in case of DNEL derivation for local effects since local irritation of respiratory tract is rather a concentration-dependent effect than time-dependent effect.

Applying of assessment factors and calculation of DNELs:

The assessment factors have been applied to the corrected starting point to obtain the endpoint specific DNELs. Assessment factors (AFs) correct uncertainties and variability within and between species in the effect data.

Interspecies differences:

The species-specific default assessment factor of 4 for allometric scaling for rats was applied in case of the oral NOAEL established in the combined repeated dose toxicity study, which was used to derive the dermal long-term DNEL. No allometric scaling factor was applied in case of derivation of the inhalation DNEL from the inhalation NOAEC. An assessment factor of 3 was applied in order to extrapolate LC50 to a non-lethal level in animals (in case of rats) and an assessment factor of 2.4 in case of rabbits.

No assessment factor of 2.5 was applied for remaining interspecies differences in toxicodynamics between rat and human because according to the ECETOC approach this AF is already accounted by total allometry.

Intraspecies differences:

An assessment factor of 3 was applied for workers in cases of DNEL derivation for systemic effects by long-term exposure. An assessment factor of 3 was applied in order to extrapolate LC50 and LD50 to a non-lethal level in humans. A combined AF of 1 for inter- and intraspecies variability (non-lethal concentration in animals and in humans) was applied to LOAEC (POD) to derive short-term DNEL for local effects.

Extrapolation of duration:

An assessment factor of 1 was applied for duration of exposure when acute study was used for the derivation of the acute dermal DNEL and in case of DNELs for local effects.

An assessment factor of 2 was applied in case of derivation of inhalation long-term DNEL from NOAEC from inhalation subchronic study (Lynch et al., 1990).

An assessment factor of 2 was applied for duration of exposure in case of derivation of dermal DNEL for long-term exposure by route-to-route extrapolation using NOAEL from oral combined repeated dose and reproductive/developmental toxicity (Takashima et al., 2003). Males were exposed 42 days to test material; females were exposed 14 days before mating, throughout the gestation (21 days) and lactation (21 days) resulting in 56 days (exposure duration is neither sub-acute nor sub-chronic). "Compounds, such as most industrial chemicals, that have relatively short-half lives, are not reactive to tissue components and do not deplete essential elements, might have NOAEL in 28-day studies close to those for chronic studies" is mentioned in the ECETOC Technical Report No.86 "Derivation of Assessment Factors for Human Health Risk Assessment". Based on the toxicokinetic behaviour of the structural analogues, tripropylamine is expected to have short half-life in the body and be rapidly metabolised and excreted; tripropylamine is assessed as not reactive chemical to the tissues depleting essentials structures. Moreover, toxicity pattern observed in the repeated dose toxicity studies point to irritation as primary effect while systemic effects could not be reached or were less pronounced. Therefore, the oral NOAEL of 40 mg/kg bw established in the combined study is expected to be close to one of subchronic duration and therefore the assessment factor of 2 is considered appropriate.

In case of derivation of short-term systemic DNEL for inhalation, Haber's law is applied to extrapolate long-term duration to short-term duration.

Quality of whole data base:

The assessment factors for uncertainties to the quality of the data base are used: 1 in cases where the data on the substance of interest has been used and an assessment factor of 2 is applied for uncertainties associated with the use of read-across data since NOAELs established for the analogue tertiary amines can deviate to expected NOAELs for tripropylamine.

Issues related to dose response:

A default assessment factor of 1 is applied when NOAEL was used. An assessment factor of 3 is used to cover extrapolation of LOAEC to NOAEC (in case of calculation inhalation long-term DNEL for local effects). An assessment factor of 10 is used to cover extrapolation of LOAEC (POD) to a non-toxic level in humans since no dose response was reported or dose response was not clear (in case of calculation of short-term DNELs for systemic and local effects).

Endpoint specific issues:

An assessment factor of 100 is applied to LC50 (LD50) to derive short-term DNELs since dose-response is unknown (section of 4.2.2. of ECETOC Guidance No.110; similar to approach described in REACH R.8).

Calculation of DNELs:

Long-term exposure by inhalation – systemic effects:

NOAEC of 247 ppm (1444.4 mg/m³) is modified to the corrected starting point:

Corrected NOAEC = inhalatory NOAEC x (6h/8h) x (6.7 m³/10 m³) = 1444.4 mg/m³ x (6/8) x (6.7/10) = 725.8 mg/m³

DNEL = 725.8 mg/m³ / (3 x 2 x 1 x 2) = 60.5 mg/m³ where 3 - intraspecies, 2 - duration of exposure, 1 - dose response, 2 - quality of data base (read-across data).

Acute short-term exposure – systemic effects:

LC50 of 4.5 mg/L (4500 mg/m³) can serve as the starting point (POD (point of departure)) for the DNEL derivation.

The inhalation rat LC50 of 4500 mg/m³ was adjusted for exposure duration because the animals were exposed to tripropylamine by inhalation during 1 hour. Therefore, the LD50 is corrected to a dose descriptor representing 15 minutes exposure using the modified Haber's law (Gaylor, 2000): in case of extrapolation from longer to shorter durations of exposure (C³ x t) = (C') ³ x t', giving C' = C x (t/t') E0.333. C' is sought concentration. C' = 4500 x (1h/0.25h) ^0.333 = 7140 mg/m³;

DNEL = 7140 mg/m³ / (3 x 3 x 10 x 1) = 79.3 mg/m³ where 3 - an assessment factor to estimate non-lethal level in animals, 3 - non-lethal level in humans, 10 - non-toxic level in humans (unknown dose-response curve), 1 - quality of data base (study was conducted with tripropylamine).

As an alternative, taken 2.1 mg/L (2100 mg/m³) the highest non-lethal level in animals from the following-up study (Biosearch, 1976), and adjusting it to 15 -min exposure (C' = 2100 x (1h/0.25h)^0.333 = 3332 mg/m³) the DNEL would be:

DNEL = 3332 mg/m³ / (3 x 10 x 1) = 110 mg/m³ where AFs are: 3 - non-lethal level in humans, 10 - non-toxic level in humans (no clear dose response), 1 -quality of data base (study conducted with tripropylamine). No assessment factor for non-lethal level in animals is needed since neither deaths nor significant signs of irritation were observed at 2100 mg/m³.

Long-term exposure by inhalation - local effects

NOAEC of 247 ppm (1444.4 mg/m³) is simultaneously the LOAEC for irritation and local effects.

Corrected LOAEC = inhalatory LOAEC = 1444.4 mg/m³ since no time scaling (6/8) and no adjustment in respiratory rates by rest and light activity (6.7/10) is proposed in case of irritation (local effects).

DNEL = 1444.4 mg/m³ /(3 x 3 x 2 x 1) = 80.2 mg/m³ where 3 - intraspecies, 3 - dose-response (LOAEC to NOAEC), 2 - quality of data base (read-across data), 1 - quality of data base.

As alternative, DNEL for local effects can be derived using a clear NOEC of 25 ppm, the concentration at which no irritation effects to respiratory tract was observed in exposed animals (Lynch et al., 1990). 25 ppm corresponds to 146.2 mg/m³.

DNEL = 146.2 mg/m³ / (3 x 2 x 1) = 24.4 mg/m³. AFs are: 3 - intraspecies, 2 - quality of data base (read-across data), 1 - dose response (NOEC is used).

Acute short-term exposure – local effects:

LOAEC of 2.1 mg/L (2100 mg/m³) is the POD for the DNEL derivation. No Haber's rule is used because "local irritation of the respiratory tract is strictly a concentration-related response, and a factor of 1 for time extrapolation should be used for exposure duration between 15 min and 4 hours".

DNEL = 2100 mg/m³ / (1 x 10 x 1) = 210 mg/m³ where AFs are: 1 - a combined AF for non-lethal level in animals and in humans in case of sensory respiratory irritation, 10 - non-toxic level in humans (no clear dose response), 1 - quality of data base. No assessment factor for non-lethal level in animals is needed since POD is the non-lethal level (no deaths were observed in exposed animals at 2100 mg/m³).

Hazard via dermal route

Long-term exposure – systemic effects:

Oral rat NOAEL of 40 mg/kg bw is equal to dermal NOAEL since no differences in absorption are considered for these routes of exposure:

Corrected dermal NOAEL = oral NOAEL x (ABS oral-rat/ABS dermal-rat) = 40 mg/kg bw x (100%/100%) = 40 mg/kg bw.

DNEL = 40 mg/kg bw/(4 x 3 x 2 x 1 x 2) = 0.83 mg/kg bw. Assessment factors are: 4 – interspecies, 3 – intraspecies, 2 – study duration (sub-chronic study), 1 – dose response (clear dose response), 2 – quality of data base (read-across data).

Acute short-term exposure – systemic effects:

The dermal acute LD50 of 430 mg/kg bw is the starting point for DNEL derivation since no differences in skin absorption between rabbits and humans are considered:

Corrected dermal LD50 = dermal rabbit LD50 x (ABS dermal-rabbit/ABS dermal-human) = 430 mg/kg bw x (100%/100%) = 430 mg/kg bw.

DNEL = 430 / (2.4 x 3 x 10 x 1 x 1) = 5.97 mg/kg bw. Assessment factors are: 2.4 - extrapolation from LD50 to a non-lethal level in animals (interspecies), 3 - extrapolation to non-lethal level in humans (intraspecies), 10 - non-toxic level in humans, 1 -study duration (setting of acute DNEL based on acute study), 1 – quality of data base (study conducted with tripropylamine).

Long-term exposure - local effects

Long-term dermal DNEL for local effects should be sufficiently covered by the long-term dermal DNEL for systemic effects.

Acute short-term exposure – local effects:

The DNEL for acute systemic effects should cover sufficiently local effects.

Selection of the leading health effects and the corresponding DNELs

The critical DNELs should be the lowest DNELs obtained for each exposure pattern. Systemic and local effects should be assessed using the corresponding long-term DNELs. As seen from the data of available studies for the target chemical and analogues substances, corrosivity is an underlying health effect and systemic effects cannot be reached. Since local effects usually occur at concentrations much lower than systemic effects, protective DNELs should be based on local effects.

Inhalation exposure

For long-term exposure by inhalation, the lowest DNEL of 24.4 mg/m³ is derived for local effects. The DNEL is based on NOEC of 25 ppm (TEA), the concentration at which neither systemic nor local effects were observed in treated animals (Lynch et al., 1990). For short-term exposure by inhalation, the systemic DNELs are 79.3 mg/³ and 110 mg/m³, based on LC50 and on acute LOAEC, respectively. For local effects, DNEL of 210 mg/m³ is based on acute LOAEC. The short-term DNELs are in a good correlation with long-term DNELs. However, the DNELs are derived from data of different data sources (read-across substance TEA and tripropylamine). It can contribute to an additional uncertainty.

Since irritation effects are largely based on the pKa values which do not differ strongly between primary, secondary and tertiary amines (Morrison and Boyd, 1987), it is proposed to compare existing OEL values for other alkylamines. The OEL values for primary, secondary and tertiary amines range from 2 to 5 ppm and are based on experimental results and human experience at the workplace is also taken into consideration. Therefore, they can serve as DNEL for workers. In analogy to the nearest analogue TEA, it is proposed to use 1 ppm (5.84 mg/m³ for TnPA) as DNEL for tripropylamine for long-term exposure and 2 ppm (11.7 mg/m³ for TnPA) as DNEL for short-term exposure by inhalation. German OEL of 1 ppm exists for the analogue substance TEA (TRGS 900, 2010), while no short-term OEL is mentioned in this document. Hence, an approach described by MAK Commission for chemicals with a similar toxicological profile is chosen for derivation of safe acute exposure limit. For local irritants, an excursion factor of 1 is proposed by MAK Commission but substance-specific excursion factors should be considered in case if there is sufficient information on related chemicals. German short term OEL for TEA exists in GESTIS Database which is 2 ppm (this approach is also outlined in the ECHA Guidance R.8, whereby short-term DNEL can be obtained by multiplying a long-term DNEL with afactor of 1 - 5). The proposed DNELs are lower than the DNELs calculated from animal studies but they are in a good correlation with them and will ensure with a high likelihood that no risk of systemic and/or local injury will occur in humans.

Dermal exposure

The risk of irritating (local) effects by dermal route of exposure should be controlled qualitatively in case of both long-term and short-term durations. However, dermal short-term DNEL of 5.97 mg/kg bw for acute systemic effects is appropriate for remaining risks (after RMMs and OCs are implemented) and for accidental cases. Long-term dermal DNEL of 0.83 mg/kg bw protects sufficiently against systemic and local effects.

Literature:

1. TRGS 900 Die Technischen Regeln für Gefahrstoffe. Arbeitsplatzgrenzwerte. January, 2006, zuletzt geändert und ergänzt: GMBl 2010 Nr. 34S. 746-747 (v. 21.6.2010);

2. Gaylor (2000) The use of Haber’s Law in standard setting and risk assessment. Toxicology 149 (2000) 17–19.

3. Morrison and Boyd (1987) Organic Chemistry, New York University. ISBN 0-205-08452-4

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population



















No consumer uses are intended for tripropylamine.