Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Not a GLP or O.E.C.D. Testing Guideline study with few details on experimental dosing and results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
GLP compliance:
no
Test type:
fixed concentration procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Vinyl 2-ethylhexanoate
EC Number:
202-297-4
EC Name:
Vinyl 2-ethylhexanoate
Cas Number:
94-04-2
Molecular formula:
C10H18O2
IUPAC Name:
ethenyl 2-ethylhexanoate

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
6 h
Concentrations:
Saturated air
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
A single static ihalation exposure to substantially saturated vapor for 6 hours. The vapor is produced by enclosing approximately 100g of the test material in a sealed 100 to 152 liter animal chamber for approximately 18 hours. A mixing fan periodically agitates the chamber atmosphere to aid in distribution of the vapor. Oxygen is added as need to maintain concentration at 20%.

Results and discussion

Effect levels
Sex:
male/female
Exp. duration:
6 h
Remarks on result:
other: No deaths or toxic effects from substantially saturated vapor.
Mortality:
None
Clinical signs:
other: None
Body weight:
No weight change fromtoxic effect
Gross pathology:
None

Any other information on results incl. tables

Substantially saturated vapor killed 0 of 5 male rats and 0 of 5 female rats after 6 hours of exposure.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Conclusions:
Vinyl 2-ethylhexanoate is practically nontoxic via inhalation of substantially saturated vapor.
Executive summary:

None of the 10 rats male and female exposed to vinyl 2 -ethylhexanoate had any deaths or observed toxic effects. Vinyl 2-ethylhexanoate is practically nontoxic via inhalation of substantially saturated vapor.