Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Not a GLP or O.E.C.D. Testing Guideline study with few details on experimental dosing and results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Vinyl 2-ethylhexanoate
EC Number:
202-297-4
EC Name:
Vinyl 2-ethylhexanoate
Cas Number:
94-04-2
Molecular formula:
C10H18O2
IUPAC Name:
ethenyl 2-ethylhexanoate

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
16.0, 11.3, 8.0, 5.7, 4.0 and 2.0 ml/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
Adult male and female Sprague-Dawley rats were used in this experiment. Rats were dosed with undiluted vinyl 2-ethylhexanoate at (2.0, 4.0, 5.7, 8.0, 11.3, 16.0 ml/kg) by intraesophageal intubation. Food and water were freely available throughout a 14 day observation period.

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
5.47 mL/kg bw
Sex:
male
Dose descriptor:
LD50
Effect level:
9.54 mL/kg bw
Mortality:
Males: 5/5 at 16.0 ml/kg and 5/5 at 11.3 ml/kg
Females: 2/2 at 16.0 ml/kg and 5/5 at 8.0 ml/kg, 2/5 at 5.7 ml/kg
Clinical signs:
Sluggishness, unstaidy gait, prostration, red crust on perinasal fur, brown wet stain on periurogenital fur.
Body weight:
Survivors demonstrated an increase in body weight,
Gross pathology:
Lung mottled red and dark red, dark red kidneys ans trace to large amount of blood in urine at high dose levels in males, 16.0 and 11.3 ml/kg. The effects were seen at lower doses, down to 5.7 ml/kg, in females.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Males: LD50 = 9.54 ml/kg; Females: LD50 = 5.47 ml/kg; No significant lesions observed from microscopic evaluation.
Executive summary:

Males: LD50 = 9.54 ml/kg; Females: LD50 = 5.47 ml/kg; No significant lesions observed from microscopic evaluation. Vinyl 2 -ethylhexanoate is of low acute toxicity to laboratory rats by the oral routes of exposure.