Registration Dossier

Administrative data

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
31 December 2004 to 23 May 2005
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study was conducted in 2005 according to EU and OECD Method and in accordance with GLP. The study material is well characterized

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling point/boiling range)
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
31 December 2004 to 23 May 2005

Results and discussion

Boiling point
Boiling pt.:
ca. 304.6 °C
Decomposition:
yes
Decomp. temp.:
ca. 380 °C

Any other information on results incl. tables

Test 1

A melting endotherm was observed with a peak temperature of 180.0°C. A second endotherm was observed, due to the boiling point, with a peak temperature of 303.3°C. An unsteady baseline was subsequently observed, starting at ca. 380°C, indicative of

decomposition of residue.

Test 2

A melting endotherm was observed with a peak temperature of 180.3°C. A second endotherm was observed, due to the boiling point, with a peak temperature of 305.8°C.

Applicant's summary and conclusion

Conclusions:
The thermal behaviour of BMS 528233-01 was assessed by Differential Scanning Calorimetry. A melting endotherm was observed with a peak temperature of 180.2°C. A second endotherm was observed, due to the boiling point, with a peak temperature of 304.6°C. An unsteady baseline was also observed, starting at ca. 380°C, indicative of decomposition of residue.
Executive summary:

 A melting endotherm was observed with a peak at 180.2°C, followed by a probable boiling endotherm with a peak temperature of 304.6°C.

The melting point is defined as the temperature at which the phase transition from solid to liquid state takes place. Similarly, the boiling point is defined as the temperature at which the saturated vapour pressure of a liquid is the same as the standard (atmospheric) pressure.

Both the melting and boiling point of the test substance were determined by differential scanning calorimetry (DSC). This is a technique in which a sample and a thermally inert reference material are subjected to a programmed temperature increase that is linearly ramped with time. The sample or reference is heated to maintain zero temperature difference, and the energy is plotted as a function of the programmed temperature. This provides a direct calorimetric measure of the energy of the reaction or transition. For example, if substance and empty reference pans are heated over the test substance's solid to liquid-phase transition temperature, the energy required to melt the test substance can be determined along with the actual melting temperature. The boiling or decomposition parameters can similarly be determined.