Registration Dossier
Registration Dossier
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EC number: 212-751-3 | CAS number: 866-81-9
Endpoint summary
Administrative data
Description of key information
Tricobalt dicitrate is not irritating to the skin but causes irreversible effects on the eyes.
Key value for chemical safety assessment
Additional information
Skin irritation
Tricobalt dicitrate was in a reliable study according to OECD 404 in albino New Zealand rabbits (Colas, 2010). No cutaneous reactions (erythema and oedema) were observed on the treated area during an observation period of 72 hours, so Tricobalt dicitrate was not irritating to skin.
Eye irritation
The eye irritation potential of Tricobalt dicitrate was investigated according to OECD 405 under GLP conditions (Colas, 2010). After one hour, the eyes of two animals were rinsed, the treated eye of the third animal remained unwashed. The ocular reactions observed during the study have been slight to important and partially reversible. A moderate redness associated with a moderate to important chemosis was noted 1 hour after the test item instillation. The redness was totally reversible in two animals but persisted in the third animal on day 21 (last day of the test, slight intensity). The chemosis was totally reversible after 10 days. A slight and reversible corneal opacity was observed in one animal 24 hours after instillation. A congestion at the iris was noted 24 hours after the test item instillation in one animal which was totally reversible after 2 days. In one animal, the presence of a white spot on the nictitating membrane was noted on day 2 and was associated with a white spot on the lower eyelid on day 6. These reactions remained on day 21. In another animal, the presence of a white spot on the nictitating membrane was noted between day 2 and day 8 and on day 2 on the lower eyelid. This reaction was totally reversible. Under the conditions of the test, Cobalt citrate had irreversible effects on the eye.Justification for classification or non-classification
Based on available data, tricobalt dicitrate has to be classified:
Skin irritation
There is conclusive data available which is not sufficient for classification.
Eye irritation
DSD: R41
CLP: Eye damage category 1
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