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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: publication does not give sufficient experimental details

Data source

Reference
Reference Type:
publication
Title:
Comparative Toxicity of Mercaptobenzimidazole and N-phenyl-N-isopropylparaphenyleneamine
Author:
Vorob'eva RS et al.
Year:
1963
Bibliographic source:
Sov. Rubber Technol. 22, 11-12

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
15 d
Frequency of treatment:
2 h/d
Doses / concentrations
Remarks:
Doses / Concentrations:
300-400 mg/m3
Basis:

Control animals:
yes
Details on study design:
Post-exposure period: no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
bw gain unchanged, functional state of the nervous system
of some rats changed, malfunction of the liver, decreased
liver weight, kidney and heart weight unchanged, no morpho-
logical changes of the organs.

Applicant's summary and conclusion