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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: publication does not give sufficient experimental details

Data source

Reference
Reference Type:
publication
Title:
Excretion kinetics of the rubber anti-oxidant N-isopropyl-N'-phenyl-p-phenylendiamine (IPPD)
Author:
Scansetti, G. et al.
Year:
1987
Bibliographic source:
Int. Arch. Occup. Environ. Health 59, 537-543

Materials and methods

Principles of method if other than guideline:
other: biomonitoring study

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IPPD

Test animals

Species:
human

Results and discussion

Main ADME results
Type:
other: biomonitoring data
Results:
IPPD was detected in exposed workers, a fast and a low excretion rate is suggested

Toxicokinetic / pharmacokinetic studies

Details on excretion:
IPPD was detected in exposed workers, a fast and a low excretion rate is suggested

Any other information on results incl. tables

Increase of IPPD urinary excretion during the working day was rapid; IPPD concentrations in the urine were always significantly higher in the end- than in the before-shift sample (mean 83.57 vs. 19.55 µg/l; P<0.001, two-tailed; Wilcoxon matched pairs signed-ranks test).

During the week some accumulation occured as before-shift values were higher at the end of the working week than at the beginning, the differences between paired values on monday and on friday is significant (mean 10.8 vs. 25.8 µg/l, p<0.005 two-tailed).

A fast and a slower component of IPPD excetion kinetics is suggested; the slower component of IPPD excretion kinetics appeared from the comparision between end-shift values and before-shift values on the next working day (mean 87.16 vs. 21.92 µg/l, p<0.001 two-tailed); the differences was highly significant, indicating rapid elimination in the hours following exposure; the same is suggested comparing the end-shift values on friday and before-shift values on the following monday (mean 76.21 vs. 10.92 µg/l, p<0.001, two tailed).

Applicant's summary and conclusion