Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

There are only limited documented publications available, which describes the toxiciokinetics of IPPD in humans and/or animals.

In a limited reported human study, urine was collected twice daily (pre- and post-shift) over a 2 week period from 16 workers exposed to IPPD (Scansetti 1987). No information was provided as to the route, level or duration of exposure. The weekly mean levels of IPPD in the urine were reported to increase from 19.55 to 82.57µg/l for pre- to post-shift, respectively. During the working week there was also some evidence of accumulation of IPPD in the body with the pre-shift urine levels increased from 10.8 to 25.8µg/l for Monday to Friday, respectively. A fast and a slower component of IPPD excretion kinetics with the urine are suggested.

In a limited documented publication (Scansetti 1987) the skin absorption of IPPD was evaluated with a human volunteer. The volunteer immersed one hand in the 10 litters of cold water containing 2g of indissoluble IPPD for 90 minutes. Urine samples were collected in intervals over 7 days. IPPD was detected in the urine 3 hours after the end of exposure and ceased to be detected in the urine 7 days after exposure. This study provides evidence of dermal absorption of IPPD; however due to the limited documentation, the data should be used only for supporting reasons.

In addition, absorption by inhalation is supported by limited documented publications. IPPD was detected in the urine of workers exposed to IPPD by the inhalation or/ and dermal route (Scansetti 1983, Carlucci 1984, Pavan 1987).

The major metabolite of IPPD identified in rabbits was a N-glucuronide (Saito 1980).