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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: short report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
Due to the age of the study, deficiencies in study conduct and reporting.
Principles of method if other than guideline:
500 mg/animal were applied onto the ear, washing of the ear with water and soap/ vegetable oil; post observation period: 7 days
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Zinc ferrite brown spinel
EC Number:
269-103-8
EC Name:
Zinc ferrite brown spinel
Cas Number:
68187-51-9
Molecular formula:
ZnFe2O4
IUPAC Name:
Zinc ferrite brown spinel
Test material form:
solid: particulate/powder

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 3 - 4 kg
- Housing: individual
- male and female

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg/ animal
Duration of treatment / exposure:
24 hour(s)
Observation period:
7 days
Number of animals:
2

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
4
Reversibility:
other: no effects
Remarks on result:
no indication of irritation
Remarks:
24 and 72 h not determined; after 7 days also no effects
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
4
Reversibility:
other: no effects
Remarks on result:
no indication of irritation
Remarks:
24 and 72 h not determined; after 7 days also no effects
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
4
Reversibility:
other: no effects
Remarks on result:
no indication of irritation
Remarks:
24 and 72 h not determined; after 7 days also no effects
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
4
Reversibility:
other: no effects
Remarks on result:
no indication of irritation
Remarks:
24 and 72 h not determined; after 7 days also no effects

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The test item is not irritating to the skin and does not require classification and labelling.
Executive summary:

500 mg/animal were applied onto the ear, washing of the ear; post observation period: 7 days

result: not irritating