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Description of key information

Valid studies for skin irritation/corrosion and eye irritation are available for zinc ferrite brown spinel.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: short report
Principles of method if other than guideline:
500 mg/animal were applied onto the ear, washing of the ear; post observation period: 7 days
GLP compliance:
not specified
Species:
rabbit
Strain:
New Zealand White
Type of coverage:
semiocclusive
Vehicle:
not specified
Controls:
not required
Amount / concentration applied:
undiluted
Duration of treatment / exposure:
24 hour(s)
Observation period:
7 days
Number of animals:
2
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: after removal, 2d, 7 d
Score:
0
Max. score:
8
Remarks on result:
other: no findings at any time point
Interpretation of results:
not irritating
Remarks:
Migrated information
Executive summary:

500 mg/animal were applied onto the ear, washing of the ear; post observation period: 7 days

result: not irritating

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: short report
Principles of method if other than guideline:
50 mg/animal was applied into the conjunctival sac, post observation time 7 days
GLP compliance:
not specified
Species:
rabbit
Strain:
New Zealand White
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
Amount applied: 50 mg/animal
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
2
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24 h, 2, 3, 7 d
Score:
0
Max. score:
13
Remarks on result:
other: no findings at any time point
Interpretation of results:
not irritating
Remarks:
Migrated information
Executive summary:

50 mg/animal was applied into the conjunctival sac, postobservation time 7 days

result: not primary irritant

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

In the available studies zinc ferrite brown spinel was not irritating to the eye and to the skin.


Justification for selection of skin irritation / corrosion endpoint:
Key study is used

Justification for selection of eye irritation endpoint:
key study is used

Justification for classification or non-classification

Due to the results of the available studies for zinc ferrite brown spinel a classification is not justified.

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