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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1976
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Significant methodological deficiencies.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
Dose was not provided. Source, purity, chemical characteristics of test substance, temperature, light cycle, and humidity not provided; quantitative results not provided
GLP compliance:
no
Remarks:
study pre-dates GLP requirements
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,4-triazole
EC Number:
206-022-9
EC Name:
1,2,4-triazole
Cas Number:
288-88-0
Molecular formula:
C2H3N3
IUPAC Name:
1H-1,2,4-triazole
Details on test material:
- Name of test material (as cited in study report): 1,2,4-triazole
- Analytical purity: reported as technically pure

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: from the breeder Winkelmann (Borchen)
- Age at study initiation: no data
- Weight at study initiation: 18-22g
- Fasting period before study: no data
- Housing: in tyupe-III Makrolon cages
- Diet (e.g. ad libitum): Altromin R standard diet, ad libitum
- Water (e.g. ad libitum): not precised, ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS: no data

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
The inhalation was carried out in 10 litre inhalation chambers. Air was passed at 2 litres per minutes through test article in a dust tower. The resulting air, enriched with vapor and dust was administered to the animals for inhalation.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Concentrations:
Not reported
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
14 -day post observation period

Results and discussion

Mortality:
None
Clinical signs:
other: Mice tolerated the 6 hour inhalation without signs. No irritant effect on the mucous membrane of the eyes and noses of the animal was observed.

Applicant's summary and conclusion

Interpretation of results:
other: No dosage was reported, unable to classify.