Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-022-9 | CAS number: 288-88-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1976
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Significant methodological deficiencies.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Dose was not provided. Source, purity, chemical characteristics of test substance, temperature, light cycle, and humidity not provided; quantitative results not provided
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP requirements
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,2,4-triazole
- EC Number:
- 206-022-9
- EC Name:
- 1,2,4-triazole
- Cas Number:
- 288-88-0
- Molecular formula:
- C2H3N3
- IUPAC Name:
- 1H-1,2,4-triazole
- Details on test material:
- - Name of test material (as cited in study report): 1,2,4-triazole
- Analytical purity: reported as technically pure
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: from the breeder Winkelmann (Borchen)
- Age at study initiation: no data
- Weight at study initiation: 18-22g
- Fasting period before study: no data
- Housing: in tyupe-III Makrolon cages
- Diet (e.g. ad libitum): Altromin R standard diet, ad libitum
- Water (e.g. ad libitum): not precised, ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS: no data
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- The inhalation was carried out in 10 litre inhalation chambers. Air was passed at 2 litres per minutes through test article in a dust tower. The resulting air, enriched with vapor and dust was administered to the animals for inhalation.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Concentrations:
- Not reported
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- 14 -day post observation period
Results and discussion
- Mortality:
- None
- Clinical signs:
- other: Mice tolerated the 6 hour inhalation without signs. No irritant effect on the mucous membrane of the eyes and noses of the animal was observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: No dosage was reported, unable to classify.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
