Registration Dossier
Registration Dossier
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EC number: 206-022-9 | CAS number: 288-88-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1976
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Significant methodological deficiencies.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Dose was not provided. Source, purity, chemical characteristics of test substance, temperature, light cycle, and humidity not provided; quantitative results not provided
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP requirements
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,2,4-triazole
- EC Number:
- 206-022-9
- EC Name:
- 1,2,4-triazole
- Cas Number:
- 288-88-0
- Molecular formula:
- C2H3N3
- IUPAC Name:
- 1H-1,2,4-triazole
- Details on test material:
- - Name of test material (as cited in study report): 1,2,4-triazole
- Analytical purity: reported as technically pure
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: from the breeder Winkelmann (Borchen)
- Age at study initiation: no data
- Weight at study initiation: 18-22g
- Fasting period before study: no data
- Housing: in tyupe-III Makrolon cages
- Diet (e.g. ad libitum): Altromin R standard diet, ad libitum
- Water (e.g. ad libitum): not precised, ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS: no data
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- The inhalation was carried out in 10 litre inhalation chambers. Air was passed at 2 litres per minutes through test article in a dust tower. The resulting air, enriched with vapor and dust was administered to the animals for inhalation.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Concentrations:
- Not reported
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- 14 -day post observation period
Results and discussion
- Mortality:
- None
- Clinical signs:
- other: Mice tolerated the 6 hour inhalation without signs. No irritant effect on the mucous membrane of the eyes and noses of the animal was observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: No dosage was reported, unable to classify.
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