Registration Dossier
Registration Dossier
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EC number: 271-231-4 | CAS number: 68526-83-0
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Justification for type of information:
- No signs of toxicity were observed in rats inhaling 180 ppm isooctanol (maximal achievable concentration) 6 hours/day for 13 days (Gage, 1970). No maternal toxicity was seen after inhalation for 19 days of near saturated vapor concentrations of 840 ppm 1-hexanol, 200 ppm 2-EH, 65 ppm 1-octanol, 25 ppm 1-nonanol, or 15 ppm 1-decanol in a developmental toxicity study using pregnant rats (Nelson et al., 1990). It is not reasonably expected under actual use conditions for exposures to low volatility substances to be present at saturated vapor concentrations for any extended period. Containment and other technical measures prevent such vapor concentrations during manufacturing and use activities. Site measurements with direct-reading devices are used to ensure low exposure conditions.
Data source
Materials and methods
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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