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EC number: 216-940-1 | CAS number: 1704-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study (OECD 471/472) conducted in compliance with GLP regulations
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- and OECD Guideline 472 (Genetic Toxicology: Escherichia coli, Reverse Mutation Assay) (May 1983/Revised Draft, March 1996)
- Deviations:
- yes
- Remarks:
- Compared to OECD TG 471 (1997), only one positive control substance (2AA) used as the sole indicator of the efficacy of the S9-mix, a second control substance is missing.
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-[2-dimethylamino)ethoxy]ethanol
- IUPAC Name:
- 2-[2-dimethylamino)ethoxy]ethanol
- Reference substance name:
- 2-[2-(dimethylamino)ethoxy]ethanol
- EC Number:
- 216-940-1
- EC Name:
- 2-[2-(dimethylamino)ethoxy]ethanol
- Cas Number:
- 1704-62-7
- Molecular formula:
- C6H15NO2
- IUPAC Name:
- 2-[2-(dimethylamino)ethoxy]ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Dimethylaminodiglycol
- Physical state: Colorless to yellowish liquid
- Analytical purity: 99.1 area-% (GC)
- Storage condition of test material: Room temperature
Constituent 1
Constituent 2
Method
- Target gene:
- His +/-; Trp +/-
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Metabolic activation system:
- The S9 fractions were prepared from the liver of Aroclor 1254-induced male Sprague-Dawley rats.
- Test concentrations with justification for top dose:
- 0; 20; 100; 500; 2500 and 5000 µg/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: water
- Justification for choice of solvent/vehicle: good solubility
Controls
- Untreated negative controls:
- yes
- Remarks:
- sterility control
- Negative solvent / vehicle controls:
- yes
- Remarks:
- water control
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: With S-9 mix: all strains 2-aminoanthracene; without S-9 mix: strains TA100, TA1535: N-methyl-N'-nitro-N-nitrosoguanidine; TA98: 4-nitro-o-phenylendiamine; TA1537: 9-aminoacridine; E.coli WP2 uvrA: N-ethyl-N'-nitro-N-nitrosoguanidine.
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: preincubation test
DURATION
- Preincubation period: 20 min
- Exposure duration: 48 h
NUMBER OF REPLICATIONS: 3
METHOD OF APPLICATION: standard plate test (plate incorporation assay)
DURATION
- Exposure duration: 48 h
NUMBER OF REPLICATIONS: 3
DETERMINATION OF CYTOTOXICITY (in both assays)
- Method: Toxicity was detected by a
- decrease in the number of revertants
- clearing or diminution of the background lawn (= reduced his- or trp- background growth)
- reduction in the titer. - Evaluation criteria:
- The test chemical is considered positive in this assay if the following criteria are met: A dose-related and reproducible increase in the number of revertant colonies, i.e. about doubling of the spontaneous mutation rate in at least one tester strain either without S-9 mix or after adding a metabolizing system.
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- A slight decrease in the number of revertants was occasionally observed depending on the strain and test conditions at doses > 2500 µg/plate.
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- A slight decrease in the number of revertants was occasionally observed at doses of 5000 µg/plate.
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- TEST-SPECIFIC CONFOUNDING FACTORS
- Precipitation: No test substance precipitation was found.
Any other information on results incl. tables
Standard plate test (mean ± SD):
Dose (µg/plate) | TA1535 | TA100 | TA1537 | TA98 | E. coli WP2 uvrA | |||||||||||||||||||||||||||||||||||||||||
-S9 | +S9 | -S9 | +S9 | -S9 | +S9 | -S9 | +S9 | -S9 | +S9 | |||||||||||||||||||||||||||||||||||||
0 | 21±2 |
23±1 |
117±6 |
117±3 |
13±1 |
16±2 |
29±2 |
45±4 |
32±2 |
47±3 |
|
|
|
|
|
|
||||||||||||||||||||||||||||||
20 |
20±1 |
20±1 |
113±7 |
109±7 |
13±1 |
12±1 |
26±2 |
35±1 |
32±4 |
42±4 |
|
|
|
|
|
|
||||||||||||||||||||||||||||||
100 |
17±2 |
18±3 |
107±11 |
107±3 |
13±3 |
11±1 |
24±3 |
33±1 |
32±5 |
39±2 |
|
|
|
|
|
|
||||||||||||||||||||||||||||||
500 |
19±3 |
20±1 |
109±15 |
115±19 |
11±2 |
9±2 |
23±2 |
31±3 |
34±4 |
34±1 |
|
|
|
|
|
|
||||||||||||||||||||||||||||||
2500 |
19±2 |
19±1 |
104±10 |
123±9 |
11±2 |
8±1 |
24±3 |
28±1 |
31±3 |
33±3 |
|
|
|
|
|
|
||||||||||||||||||||||||||||||
5000 |
6±1 |
17±3 |
100±8 |
115±13 |
12±1 |
11±1 |
22±2 |
29±2 |
28±2 |
36±5 |
|
|
|
|
|
|
||||||||||||||||||||||||||||||
2 -AA |
- |
149±25 |
- |
1243±212 |
- | 110±5 |
- |
1127±86 |
- |
206±23 |
|
|
|
|
|
|
||||||||||||||||||||||||||||||
MNNG |
1048±64 |
- |
1116±75 |
- |
- |
- |
- |
- |
- |
- |
|
|
|
|
|
|
||||||||||||||||||||||||||||||
AAC |
- |
- |
- |
- |
732±64 |
- |
- |
- |
- |
- |
|
|
|
|
|
|
||||||||||||||||||||||||||||||
NOPD |
- |
- |
- |
- |
- |
- |
728±62 |
- |
- |
- |
|
|
|
|
|
|
||||||||||||||||||||||||||||||
ENNG |
- |
- |
- |
- |
- |
- |
- |
- |
749±69 |
- |
|
|
|
|
|
|
Preincubation-test (mean ± SD):
Dose (µg/plate) |
TA1535 |
TA100 |
TA1537 |
TA98 |
E. coli WP2 uvrA |
|
|
|
|
|
|
|
|||||||||||||||||||||||||||||||||
|
-S9 |
+S9 |
-S9 |
+S9 | -S9 | +S9 | -S9 | +S9 | -S9 | +S9 | |||||||||||||||||||||||||||||||||||
0 | 21±2 |
20±2 |
129±9 |
150±17 |
12±1 |
13±2 |
31±1 |
46±6 |
33±2 |
49±5 |
|
|
|
|
|
|
|
||||||||||||||||||||||||||||
20 |
20±3 |
19±1 |
121±8 |
166±12 |
10±1 |
10±1 |
31±1 |
43±2 |
32±3 |
45±5 |
|
|
|
|
|
|
|
||||||||||||||||||||||||||||
100 |
18±3 |
18±2 |
123±11 |
162±11 |
10±1 |
11±1 |
31±3 |
42±4 |
31±4 |
40±2 |
|
|
|
|
|
|
|
||||||||||||||||||||||||||||
500 |
15±2 |
18±1 |
117±17 |
159±13 |
9±1 |
8±1 |
26±3 |
41±3 |
26±4 |
41±3 |
|
|
|
|
|
|
|
||||||||||||||||||||||||||||
2500 |
13±1 |
16±3 |
145±16 |
160±13 |
9±2 |
7±2 |
23±3 |
31±1 |
26±7 |
37±2 |
|
|
|
|
|
|
|
||||||||||||||||||||||||||||
5000 |
9±2 |
15±2 |
126±7 |
163±15 |
6±1 |
8±1 |
24±2 |
31±1 |
22±2 |
31±1 |
|
|
|
|
|
|
|
||||||||||||||||||||||||||||
2-AA |
- |
170±29 |
- |
1593±105 |
- |
135±32 |
- |
1380±205 |
- |
233± 13 |
|
|
|
|
|
|
|
||||||||||||||||||||||||||||
MNNG |
2029±73 |
- |
2281±169 |
- |
- |
- |
- |
- |
- |
- |
|
|
|
|
|
|
|
||||||||||||||||||||||||||||
AAC |
- |
- |
- |
- |
644±58 |
- |
- |
- |
- |
- |
|
|
|
|
|
|
|
||||||||||||||||||||||||||||
NOPD |
- |
- |
- |
- |
- |
- |
871±140 |
- |
- |
- |
|
|
|
|
|
|
|
||||||||||||||||||||||||||||
ENNG | - | - | - | - |
- | - | - | - | 764±5 | - |
X: reduced background growth
2-AA: 2-aminoanthracene
MNNG; N-methyl-N-nitro-N-nitrosoguanidine
ENNG; N-ethyl-N-nitro-N-nitrosoguanidine
NOPD: 4-nitro-o-phenylendiamine
AAC: 9-aminoacridine chloride monohydrate
Under the conditions tested 2-[2-(dimethylamino)ethoxy]ethanol is non mutagenic in the bacterial AMES-test.
The positive control gave the expected response.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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