Silicic acid, aluminum salt

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific and national standards, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

occlusive dressing, abraded and intact skin

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Silicic acid, aluminum sodium salt

EC Number:

215-684-8

EC Name:

Silicic acid, aluminum sodium salt

Cas Number:

1344-00-9

Details on test material:

ZEOLEX 23A - surface area (BET): 65 -80 m2/g, pH 9.8 - 10.6

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

not specified

Administration / exposure

Type of coverage:

occlusive

Vehicle:

water

Details on dermal exposure:

The TS was applied as paste to the intact and abraded skin of 2 animals of each dose group
TEST SITE
- Area of exposure: no data
- % coverage: no data
- Type of wrap if used: impervious bandage
- The TS was applied as paste to the intact and abraded skin of 2 animals each of the dose groups; the animals with abraded skin were not taken into account for assessment of skin irritation.

REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 h

TEST MATERIAL
- Amount applied: no data
- For solids, paste formed: yes, aqueous

VEHICLE
- Amount applied: an undefined amount of water was added to the solid test material to form an aqueous paste

Duration of exposure:

24 h

Doses:

2000, 3000, 4000, and 5000 mg/kg bw as aqueous paste

No. of animals per sex per dose:

4 animals per dose; sex not specified

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

none: 0/16 (0/4 in each dose group)

Clinical signs:

All animals of all dose group appeared normal during the observation period.

Body weight:

normal

Gross pathology:

No gross pathological findings were noted.

Other findings:

Dermal reactions were limited to slight erythema and edema which were fully reversible at the latest within 4 days.