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Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

This study was made according to the method of Magnusson and Kligman and the OECD Guideline N° 406.

Applications of the induction phase were carried out by intradermal route and by topical occlusive route. By intradermal route : injection of 2 x 0.1 ml of the test substance in a 25 % (W/W) solution in water for injection ; orof 50/50 (V/V) mixture : test compound in a 50 % solution (W/W) in water for injection + 50 % (V/V) solution of Freund's complete adjuvant in water for injection,i.e.a final 25 % concentration of the test substance. The injection of the test substance in a 25 % solution did not induced any important irritation.

By topical occlusive route for 48 hours, with test substance in a 50 % (W/W) dilution with water for injection and at the dose of 0.50 ml per animal : this application having induced no irritation macroscopically noticeable, the skin was treated on D7, with 0.50 ml of 10 % Sodium Lauryl Sulfate in Codex Petrolatum.

For the challenge exposure, the occlusive topical application for 24 hours was carried out with the test substance in a 50 % (W/W) solution with water for injection and at the dose of 0.50 ml per guinea-pig.

Considering the macroscopic and histological results obtained under the conditions of the study, 1,2,4 -triazole caused a reaction of cutaneous sensitization in one out of the 20 treated guinea-pigs (5 %), no topical cutaneous abnormality was noted in the 10 control guinea-pigs.

According this study, 1,2,4 -triazole appears to be not sensitising.


Migrated from Short description of key information:
A guideline (OECD 406) study was available for this endpoint, it's a maximization test on guinea pigs. According this study, 1,2,4 -triazole appears to be not sensitising.

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
No available study.

Justification for classification or non-classification

According to EU Directive 67/584/EEC and EU regulation (EC) No 1272/2008 (CLP) :

1,2,4 -triazole sodium salt was not a skin sensitizer.

Positive result was observed in 5% of the treated animals (<30%).