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Administrative data

Description of key information

Skin irritation : Study according to OECD guideline (404) - Na1.2.4-triazole was a non skin irritant.
Eye irritation : Study according to OECD guideline (405) - Na1.2.4-triazole was a severe eye irritant.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Skin irritation (Study of Dufour 1992) :

Three rabbits were exposed by dermal route (semiocclusive) to 1,2,4-Triazole sodium salt during 4 hours according to the OECD 404 guideline. A slight irritation reaction was observed on the three rabbits' skin. These phenomena were totally reversible in 5 days. Erythema and edema scores were estimated according to the criteria of Draize. For each score and each animal, the score were between 0 and 1 at the 24, 48 and 72 hours time points observation.

Eye irritation (Study of Dufour 1992) :

One eye of one rabbit was exposed 80 mg of 1,2,4-Triazole sodium salt according to the OECD 405 guideline. The substance caused serious eye damage, and these phenomena were not reversible in 72 hours. Each scores were estimated according to the criteria of Draize. For each item, at each time, the score was the maximal score.

Important and non reversible irritation reactions are observed on the rabbit's treated eye: to the level of the conjunctiva: tumefaction with eyelids more than half closed and intense hyperhemia, iris discernible with difficulty, absence of reaction to light, important haemorrhage visible, and, opacity in the whole area of the cornea on all surface.


Effects on eye irritation: highly irritating

Justification for classification or non-classification

According to EU regulation (EC) No 1272/2008 (CLP) :

Skin irritation : 1,2,4-Triazole sodium salt was not classified (mean score < 2.3).

Eye irritation : 1,2,4-Triazole sodium salt was classified as eye irritant in category 1. Because: effects on the cornea, iris and conjunctiva were not fully reversible in 72 hours, and there are a positive response of cornea opacity (>3), and iritis (>1.5) calculated as the mean scores following grading at 1, 24, 48, and 72 hours after installation of the substance.

According to EU Directive 67/584/EEC :

Skin irritation :1,2,4-Triazole sodium salt was not classified (score < 2).

Eye irritation :1,2,4-Triazole sodium salt was classified as "Risk of serious damage to eyes - R41". Because: effects on the cornea, iris and conjunctiva were not fully reversible in 72 hours, and there are a positive response of cornea opacity (>3), and iritis (>1.5) calculated as the mean scores following grading at 1, 24, 48, and 72 hours after installation of the substance.

To sum up, 1,2,4-Triazole sodium salt was a non skin irritant, but a severe eye irritant.

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