Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Objective of study:
distribution
excretion
Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 417 (Toxicokinetics)
Deviations:
not specified
GLP compliance:
no
Remarks:
Study pre-dates GLP

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,4-triazole
EC Number:
206-022-9
EC Name:
1,2,4-triazole
Cas Number:
288-88-0
Molecular formula:
C2H3N3
IUPAC Name:
1H-1,2,4-triazole
Details on test material:
- Name of test material (as cited in study report): 1,2,4-Triazol
- Locations of the label (if radiolabelling): 14C-labelled 1,2,4-Triazol
Radiolabelling:
yes
Remarks:
14C-labelled 1,2,4-Triazol

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
other: Oral, intravenous, and intraduodenal
Vehicle:
not specified
Doses / concentrations
Remarks:
Doses / Concentrations:
0.1-100 mg/kg (intravenous); 1 mg/kg (oral); 1 mg/kg (intraduodenal)
Details on study design:
The study has been performed with 14C-labeled 1,2,4-triazol applied to the male rat. Application routes were intraveneous (0.1-100 mg/kg), oral (1 mg/kg) and intraduodenal (1 mg/kg).

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on distribution in tissues:
The applied radioactivity was evenly distributed by the circulation to all tissues. All tissue concentrations were similar and did not indicate any tissue preference. This pattern was stable and did not change until complete excretion. Full body autoradiography showed transient enhanced concentrations in the eye.
Details on excretion:
The analysis showed a nearly complete renal elimination of radioactivity in the rat. About 3-4% of the applied dose was excreted with the feces. The renal elimination occurred fast, the plasma half-life was about 12 hours and was independent of the dose applied. Experiments with animals surgically treated with a bile duct-duodenal fistula (cholangiostomy) showed that 15-20% of the applied dose was subjected to enterohepatic circulation.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results