Registration Dossier
Registration Dossier
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EC number: 606-097-1 | CAS number: 186817-80-1
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC column
- Radiolabelling:
- no
- Test temperature:
- Column temperature 35 ± 1 °C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Alliance Separation Module 2695
- Type, material and dimension of analytical (guard) column: Hypersil BDS-CN, 150 mm ± 4.6 mm i.d., dp = 5 µm
- Detection system: Dual λ Absorbance Detector 2487
MOBILE PHASES
- Type: 55/45 (v/v) methanol/water
- pH: neutral
- Solutes for dissolving test and reference substances: methanol; The stock solutions were diluted to obtain an end solution of 55/45 (v/v) methanol/water.
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column
REFERENCE SUBSTANCES
- Identity: Acetanilide, Atrazine, Monuron, 2,5-Dichloroaniline, Benzoic acid phenylester, Fenthion, Phenanthrene, 2,4-DDT
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 10 µl (7.7 µg)
- Quantity of reference substances: 10 µl (5.5 µg)
REPETITIONS
- Number of determinations: The reference substance and test substance solutions were injected in duplicate. Blank solutions were analysed by single injection.
EVALUATION
- Calculation of capacity factors k': k' = (tr - t0)/t0 where:
tr = retention time
t0 = mean column dead time
- Calculation of retention times: Taken from the HPLC chromatograms
- Determination of the log Koc value: log k' = a logKoc + b; where: a = slope, b = intercept - Analytical monitoring:
- not required
- Type:
- Koc
- Value:
- 330
- Temp.:
- 35 °C
- Remarks on result:
- other: HPLC column temperature 35 °C
- Type:
- log Koc
- Value:
- 2.52
- Temp.:
- 35 °C
- Remarks on result:
- other: HPLC column temperature 35 °C
- Details on results (HPLC method):
- HPLC chromatograms of the test substance solution and corresponding blank solution are shown in Figure 1 (see below).
- Retention times of reference substances used for calibration: See Table 1 below
- Details of fitted regression line (log k' vs. log Koc): The equation of the regression line was: log k’ = 0.264 × log Koc – 1.214 (r = 0.97, n = 16).
- Graph of regression line attached: Figure 2 (see illustration below) shows the calibration curve of the log k’ of the reference substances as function of log Koc.
- Average retention data for test substance: See Table 1 below - Validity criteria fulfilled:
- yes
- Conclusions:
- The log Koc of 2-ethylhexyl-S-lactate is 2.52.
- Executive summary:
The HPLC method using soil-adsorption-reference data was chosen for the determination of the adsorption coefficient of PURASOLV®EHL (2-ethylhexyl-S-lactate).
The Kocand log Kocvalue of the test substance was:
neutral pH
Koc
log Koc
Test substance
3.3 × 10²
2.52
Reference
Table 1: Kocof the test substance
Substance |
tr,1 |
tr,2 |
mean tr |
log Koc |
Koc |
Area |
|
|
|
|
|
|
|
Formamide (t0) |
1.961 |
1.960 |
1.961 |
|
|
|
|
|
|
|
|
|
|
Acetanilide |
2.165 |
2.165 |
|
1.26 |
|
|
Atrazine |
2.307 |
2.307 |
|
1.81 |
|
|
Monuron |
2.351 |
2.350 |
|
1.99 |
|
|
2,5-Dichloroaniline |
2.525 |
2.524 |
|
2.55 |
|
|
Benzoic acid phenylester |
2.758 |
2.757 |
|
2.87 |
|
|
Fenthion |
3.268 |
3.267 |
|
3.31 |
|
|
Phenanthrene |
3.418 |
3.417 |
|
4.09 |
|
|
2,4-DDT |
4.903 |
4.904 |
|
5.63 |
|
|
|
|
|
|
|
|
|
Impurity I |
1.301 |
1.301 |
1.301 |
<1.26 |
<1.8x101 |
0.37 |
Test substance |
2.518 |
2.517 |
2.518 |
2.52 |
3.3x102 |
98.7 |
Impurity II |
2.804 |
2.804 |
2.804 |
3.21 |
1.6x103 |
0.91 |
|
|
|
|
|
|
|
Description of key information
The log Koc of 2-ethylhexyl-S-lactate is 2.52.
Key value for chemical safety assessment
- Koc at 20 °C:
- 330
Additional information
[LogKoc: 2.52]
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