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Environmental fate & pathways

Biodegradation in water: screening tests

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biodegradation in water: ready biodegradability
Type of information:
Adequacy of study:
weight of evidence
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
Parameter ranges: In domain; Structural domain: Out of domain (Correct fragments: 90.91%; Incorrect fragments: 0%; Unknown fragments: 9.09%); Unable to mineralize: In domain
Principles of method if other than guideline:
Estimation of results of OECD screening tests on ready biodegradation in water: CATALOGIC (v5.14.1.5); CATALOGIC 301C v.11.16
GLP compliance:
Oxygen conditions:
Inoculum or test system:
activated sludge, domestic, non-adapted
Duration of test (contact time):
28 d
probability of ready biodegradability (QSAR/QSPR)
Remarks on result:
not readily biodegradable based on QSAR/QSPR prediction
half-life in days (QSAR/QSPR)
Remarks on result:
other: Primary half life: < 1 day; Ultimate half life: 2m 28d
Details on results:
Model domain similarity:
- Parametric domain: 100%
- Structural domain: 90.91% (correct fragments), 0% (incorrect fragments), 9.09% (unknown fragments)
- Mechanistic domain: 100%

Predicted BOD value: 0.20 +/- 6.92 E-3

Prediction: Not ready degradable
Validity criteria fulfilled:
Interpretation of results:
not readily biodegradable
The test substance is not readily biodegradable (according to OECD criteria)
biodegradation in water: ready biodegradability
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
Justification for type of information:
See attached justification
Reason / purpose for cross-reference:
data waiving: supporting information
Reason / purpose for cross-reference:
data waiving: supporting information

Description of key information

Poorly biodegradable.

Key value for chemical safety assessment

Additional information