Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Conclusions for Decanoic acid, mixed esters with dipentaerythritol, octanoic acid and valeric acid (EC# 270-470-1)are based on read-across from analogue substances of a known category.

 

Experimental data for skin sensitization effects are available for 3 members of the category, i.e. one Mouse local lymphnode assay (LLNA) study and two Guinea pig maximization tests (GPMT). All studies were negative. Based on structural similarity (especially same functional groups) and the available data, the substance of interest is negative for skin sensitization.

 

EC #

451-070-8

451-120-9

230-743-8

453-470-8

452-270-8

453-480-2

444-000-2

270-470-1

CAS #

70693-33-3

156559-00-1

7299-99-2

70851-05-7

-

70851-04-6

70693-38-8

68441-66-7

Avg MW

525

537

640

783

883

1012

1023

833

Skin sensitization

negative1

negative1

read-across

read-across

read-across

read-across

negative2

read-across: negative

1LLNA

2GPMT

Avg MW = Average molecular weight


Migrated from Short description of key information:
Conclusions for skin sensitising properties of Decanoic acid, mixed esters with dipentaerythritol, octanoic acid and valeric acid (EC# 270-470-1)are based on read-across from analogue substances of a known category. Based on structural similarity and the available data for category members (all tests were negative), it was concluded that the substance of interest is negative for skin sensitization.

Justification for classification or non-classification

Based on the above mentioned result, classification according to the CLP Regulation (EC) 1272/2008 and the Dangerous Substance Directive 67/548/EC is not necessary.