Registration Dossier

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
10 mg/L
Assessment factor:
10
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)

Hazard for air

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
PNEC oral

Additional information

Conclusions for Decanoic acid, mixed esters with dipentaerythritol, octanoic acid and valeric acid (EC# 270-470-1)are based on read-across from analogue substances of an existing category (pentaerythritol and dipentaerythritol esters), of which the members were notified under Directive 67/548/EEC (NONS) in 2003/2004. The term 'read-across' for the substances other than the substance of interest means that these endpoints were already read-across in the existing category.

 

Based on the similar physic-chemical properties obtained for all members of the category in combination with the available experimental data for environmental endpoints, it can be expected that all substances would cause similar environmental toxicity,despite the variation of chain length and the presence of branchedvs. linear fatty acid esters. With an average molecular weight of 640, the substance of interest, i.e. Decanoic acid, mixed esters with dipentaerythritol, octanoic acid and valeric acid (EC# 270-470-1) falls well within the average molecular weight range of the members of the category (637 – 1023).

 

At the slightly basic pH’s seen in aquatic systems, the hydrolysis of the pentaerythrithol esters may be limited for steric reasons, i.e. the ester groups are expected to be well shielded by the aliphatic substituents and thus not be accessible for hydrolytic degradation. Therefore it is expected that the substances will be present mainly unsplit and that the toxicity of the intact moiety needs to be considered.

The ability of the pentaerythrithol esters to reach the target sites in aquatic organisms will depend strongly on their solubility and their octanol-water partition coefficient. Solubility of the members of the category is in general low and the octanol-water partition coefficient is very high (EpiWin). The low solubility makes the substances less available to aquatic organisms, as the phases are not expected to mix thoroughly and the esters most probably will be present as a film on the water surface. The high octanol-water partition coefficient would allow a good uptake of the compounds by aquatic organisms if contact is established.

Since the physico-chemical properties of the pentaerythrithol esters were shown to be similar, it is expected that the compounds will behave in the same way in the aquatic environment. Uptake will be low and therefore a minimal amount of hydrolysis and metabolic products is expected in the bodies of aquatic organisms and the concomitant toxicity will be minimal.

 

Based on the above considerations, it can be concluded that the eco-toxicological properties for Decanoic acid, mixed esters with dipentaerythritol, octanoic acid and valeric acid (EC# 270-470-1) can be derived directly by read-across from known esters.

EC #

451-070-8

451-120-9

230-743-8

453-470-8

452-270-8

453-480-2

444-000-2

270-470-1

CAS #

70693-33-3

156559-00-1

7299-99-2

70851-05-7

-

70851-04-6

70693-38-8

68441-66-7

Avg MW

525

537

640

783

883

1012

1023

833

Acute Toxicity to Fish (LL50)1

[mg/L]

> 100

(>> ws)

read-across

read-across :

> 100 (>> ws)

read-across

read-across

> 100

(>> ws)

> 100

(>> ws)

read-across :

> 100 (>> ws)

Acute Toxicity to Aquatic Invertebrates (Daphnia) (EL50)1

[mg/L]

> 100

(>> ws)

read-across

read-across :

> 100 (>> ws)

read-across

read-across

> 100

(>> ws)

> 100

(>> ws)

read-across :

> 100 (>> ws)

Toxicity to Aquatic Plants (algae) (EL50)1[mg/L]

> 472

(>> ws)

> 100

(>> ws)

read-across :

> 100 (>> ws)

> 100

(>> ws)

read-across

> 100

(>> ws)

> 100

(>> ws)

read-across :

> 100 (>> ws)

Respiration inhibition

(mg/L)

no inhibition

read-across

read-across :

IC5030min>100

read-across

read-across

IC5030min

>100

IC503h

> 1000

read-across : IC5030min>100

IC503h> 1000

1Based on loading rate (LL /EL= Lethal dose/Effect level of Loading rate); WAF method used with filtration

2value = EL50

Avg MW = Average molecular weight

ws = water solubility

Conclusion on classification

The 50% effect criterion up to the water solubility has not been reached in acute studies performed with analogue substances. Based on read-across it was concluded that the substance is not readily biodegradable. Based on this and a high log Kow, the substance does not need to be classified for the environment according to DSD and CLP.