Dodecanal

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

No data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards with acceptable restrictions.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Rats fed three dose levels of test material and observed for 14 d for mortality

GLP compliance:

no

Remarks:

study predates GLP

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Dodecanal

EC Number:

203-983-6

EC Name:

Dodecanal

Cas Number:

112-54-9

Molecular formula:

C12H24O

IUPAC Name:

dodecanal

Constituent 2

Reference substance name:

RIFM-K1188

IUPAC Name:

RIFM-K1188

Details on test material:

- Name of test material (as cited in study report): RIFM-K-1188
- Substance type: No data
- Physical state: No data
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot/batch No: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 150 g to 208 g
- Fasting period before study: 16 hrs
- Housing: Stock cages prior to dosing, individually in wire-mesh cages after dosing.
- Diet: Standard laboratory diet, ad libitum
- Water: Ad libitum
- Acclimation period: 5 d

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

10.2 g/kg bw, 15.4 g/kg bw, 23.1 g/kg bw

No. of animals per sex per dose:

2 animals per sex per dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 d
- Frequency of observations and weighing: Initial and final body weights recorded
- Animals sacrificed after 14 d.
- Necropsy of all animals performed.

Statistics:

LD50s were calculated using the techniques of Weil, Thompson, and Thompson and Weil.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

23 100 mg/kg bw

Based on:

test mat.

Mortality:

Both females in the highest group died, 12-F at 12 d, 11-F at 13 d.

Clinical signs:

other: 10.2 g/kg bw dose: Hypoactivity beginning 30 min following dose administration and which lasted 2 days, ruffed fur beginning 1 h following dose administration and which lasted 1 day. 15.4 g/kg bw dose: Hypoactivity beginning 30 min following dose admini

Gross pathology:

- Necropsy of animals that died revealed haemorrhages of the stomach.
- Haemorrhages were also observed in animal 10-M (23.1 g/kg bw dose level).
- No other gross pathological alterations were noted.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information

Conclusions:

The test substance was assessed for acute oral toxicity in rats. Under the conditions of the test, the test substance had an LD50 of 23100 mg/kg bw.