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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1957
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
very little detail on test item, laboratory and test design given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1957
Report date:
1957

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The test item was applied on five consecutive days on rat and mouse skin.
GLP compliance:
no
Test type:
other: single dose, given for five consecutive days
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2H-benzotriazol-2-yl)-p-cresol
EC Number:
219-470-5
EC Name:
2-(2H-benzotriazol-2-yl)-p-cresol
Cas Number:
2440-22-4
Molecular formula:
C13H11N3O
IUPAC Name:
2-(2H-1,2,3-benzotriazol-2-yl)-4-methylphenol
Test material form:
solid
Specific details on test material used for the study:
G 32169/1 synthesized 3.5.1957

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: 5% arabic gum
Details on dermal exposure:
back of animal was shaved. Test item was applied to the same site on five consecutive days
Duration of exposure:
5 days
Doses:
reportd as "400 ccm per rat per day"
approximately 2000 mg/kg bw/day
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
8 days post-treatment observation period.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD0
Effect level:
> 2 000 mg/kg bw
Remarks on result:
other: for 5 days
Mortality:
none

Applicant's summary and conclusion