Registration Dossier
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EC number: 219-470-5 | CAS number: 2440-22-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1957
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- very little detail on test item, laboratory and test design given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test item was applied on five consecutive days on rat and mouse skin.
- GLP compliance:
- no
- Test type:
- other: single dose, given for five consecutive days
- Limit test:
- yes
Test material
- Reference substance name:
- 2-(2H-benzotriazol-2-yl)-p-cresol
- EC Number:
- 219-470-5
- EC Name:
- 2-(2H-benzotriazol-2-yl)-p-cresol
- Cas Number:
- 2440-22-4
- Molecular formula:
- C13H11N3O
- IUPAC Name:
- 2-(2H-1,2,3-benzotriazol-2-yl)-4-methylphenol
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- G 32169/1 synthesized 3.5.1957
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: 5% arabic gum
- Details on dermal exposure:
- back of animal was shaved. Test item was applied to the same site on five consecutive days
- Duration of exposure:
- 5 days
- Doses:
- reportd as "400 ccm per rat per day"
approximately 2000 mg/kg bw/day - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- 8 days post-treatment observation period.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: for 5 days
- Mortality:
- none
Applicant's summary and conclusion
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