## Registration Dossier

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** EC number: 203-612-8 | CAS number: 108-74-7 **

- Life Cycle description
- Uses advised against

- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information

- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour

- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms

- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information

- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

## Ecotoxicological Summary

### Administrative data

### Hazard for aquatic organisms

#### Freshwater

- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 1.9 µg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 19 µg/L

#### Marine water

- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.19 µg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
- PNEC marine water (intermittent releases):
- 1.9 µg/L

#### STP

- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 0.304 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor

#### Sediment (freshwater)

- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 6.84 µg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method

#### Sediment (marine water)

- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.684 µg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method

### Hazard for air

#### Air

- Hazard assessment conclusion:
- no hazard identified

### Hazard for terrestrial organisms

#### Soil

- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.253 µg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method

### Hazard for predators

#### Secondary poisoning

- Hazard assessment conclusion:
- no potential for bioaccumulation

### Additional information

PNEC_{sediment-freshwater} was estimated using equilibrium partitioning theory as described in ECHA Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.10

A summary of the calculations are provided:

PNECsediment-freshwater = (K_{susp}_{-water}/RHO_{susp}) x PNEC_{water }x 1000 x CONV_{sed} (Equation 1)

= (0.900/1150) x 0.0019 x 1000 x 4.6

= 0.00684 mg/kg dwt

where:

PNEC_{water}= 0.0019 mg/L

RHO_{susp}= 1150 kg/m^{-3}

K_{susp-water}= 0.900 m^{3}/m^{-3 }(See Equation 2)

CONV_{sed} = 4.6 kg/kg

__Intermediate Values:__

K_{susp-water}= K_{air-water}+ Fwater_{susp}+ Fsolid_{susp }x (Kp_{susp}/1000) x RHO_{solid }**(Equation 2)**

where:

K_{air-water }= 5.30 x 10^{-5} (See Equation 3)

Fwater_{susp }= 0.9 m^{3}/m^{-3}

Fsolid_{susp }= 0.1 m^{3}/m^{-3}

Kp_{susp }= 0.001 L/kg (See Equation 4)

RHO_{solid }= 2,500

K_{air-water}= Henry / (R x Temp) **(Equation 3)**

where:

Henry = 0.13 Pa/m3/mol

R = 8.314

Temp: 285K

Kp_{susp} = Foc_{susp} x Koc **(Equation 4)**

where:

Foc_{susp} = 0.1 L/kg

Koc = 0.01 L/kg

PNEC_{sediment-marine}was estimated using equilibrium partitioning theory as described in ECHA Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.10

A summary of the calculations are provided:

PNECsediment-marine = (K_{susp}_{-water}/RHO_{susp}) x PNEC_{marine }x 1000 x CONV_{sed} **(Equation 5)**

= (0.900/1150) x 0.00019 x 1000 x 4.6

= 0.000684 mg/kg dwt

where:

PNEC_{marine}= 0.00019 mg/L

RHO_{susp}= 1150 kg/m^{-3}

K_{susp-water}= 0.900 m^{3}/m^{-3 }(See Equation 6)

CONV_{sed} = 4.6 kg/kg

__Intermediate Values:__

K_{susp-water}=K_{air-water}+ Fwater_{susp}+ Fsolid_{susp}x (Kp_{susp}/1000) x RHO_{solid }**(Equation 6)**

where:

K_{air-water}= 5.30 x 10^{ -5 }(See Equation 7)

Fwater_{susp}= 0.9 m^{3}/m^{-3}

Fsolid_{susp}= 0.1 m^{3}/m^{-3}

Kp_{susp}= 0.900 L/kg (See Equation 8)

RHO_{solid}= 2,500

K_{air-water}= Henry / (R x Temp) **(Equation 3)**

where:

Henry = 82,680 Pa/m3/mol

R = 8.314

Temp: 285K

Kp_{susp}= Foc_{susp}x Koc **(Equation 4)**

where:

Foc_{susp}= 0.1 L/kg

Koc = 0.01 L/kg

PNEC_{soil }was estimated using equilibrium partitioning theory as described in ECHA Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.10

A summary of the calculations are provided:

PNEC_{soil} =(K_{soil}_{-water}/RHO_{soil}) x PNEC_{water }x 1000 x CONV_{soil} **(Equation 7)**

= (0.200/1700) x 0.0019 x 1000 x 1.13

= 0.000253 mg/kg dwt

where:

PNEC_{water }= 0.0019 mg/L

RHO_{soil }= 1700 kg/m^{-3}

K_{soil-water}= 0.200 m^{3}/m^{-3}(See Equation 8)

CONV_{soil} = 1.13 kg/kg

__Intermediate Values:__

K_{soil-water}= Fair_{soil} x K_{air-water}+ Fwater_{soil}+ Fsolid_{soil }x (Kp_{soil}/1000) x RHO_{solid }**(Equation 8)**

where:

Fair_{soil }= 0.2 m^{3}/m^{-3}

K_{air-water}= 5.30 x 10^{-5}(See Equation 9)

Fwater_{soil }= 0.2 m^{3}/m^{-3}

Fsolid_{soil }= 0.6 m^{3}/m^{-3}

Kp_{soil }= 0.0001 L/kg (See Equation 10)

RHO_{solid}= 2,500

K_{air-water}= Henry / (R x Temp) **(Equation 9)**

where:

Henry = 82,680 Pa/m3/mol

R = 8.314

Temp: 285K

Kp_{soil}= Foc_{soil}x Koc **(Equation 10)**

where:

Foc_{soil }= 0.02 L/kg

Koc = 0.01 L/kg

### Conclusion on classification

In accordance with the criteria laid down in Regulation (EC) No 1272/2008, the substance meets the criteria for classification as Aquatic Chronic 3, H412: Harmful to aquatic life with long lasting effects.

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