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Physical & Chemical properties

Stability in organic solvents and identity of relevant degradation products

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Reference
Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09 October 2009 – 09 October 2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
This study has been performed according to OECD and EC guidelines and according to GLP principles.
Qualifier:
no guideline available
Principles of method if other than guideline:
The test substance was considered stable in DMSO if the relative difference between stored and freshly prepared solutions was ≤ 10%.
GLP compliance:
yes (incl. certificate)
Test substance stable:
yes
Transformation products:
no
Conclusions:
Stock solutions of the test substance were prepared in DMSO at target concentration levels of 0.336, 3.36 and 134 mg/mL. These levels correspond with test substance concentrations of 1, 10 and 400 mg/mL. The solutions were stored at room temperature under normal laboratory light conditions for 0, 1 and 4 hours. Based on the results obtained it was concluded that the DMSO stock solutions at the entire concentration range were stable when stored at room temperature under normal laboratory light conditions for at least 4 hours.

Description of key information

Stability in DMSO (Oudhoff, 2010): Stable = Yes, Degradation Products = No

Additional information

In a stability study conducted by Oudhoff (2010), the substance was found to be stable in DMSO, with no degradation products formed.