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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Dose descriptor:
NOAEL
60 mg/kg bw/day
Effect on fertility: via dermal route
Dose descriptor:
NOAEL
60 mg/kg bw/day
Additional information

The NOAELs are based on observed changes in relative organ weights of testis and ovaries. There is no evidence of histopathology of the reproductive organs and no indication of adverse effects in fertility. The reproductive NOAEL is at least three-fold higher than the NOAEL for general toxicity effects. This suggests that 2-VP does not selectively target the reproductive organs. Regulatory action based on the NOAEL for systemic toxicity will insure protection of specific reproductive effects.


Short description of key information:
Review of the toxicity of reproductive organs in rats after subchronic exposure to 2VP indicates only generalized toxicity at doses higher than those showing systemic toxicity. This indicates that 2-VP does not selectively target the reproductive organs. Regulatory action to protect against systemic toxicity will insure protection against specific reproductive effects

Effects on developmental toxicity

Additional information

Risk assessment for teratogenicity is performed qualitatively, based on a categorical structure-activity relationship (SAR). Using a validated SAR model of teratogenicity in humans based on 323 chemical substances, 2VP was predicted to be "inactive" or "not teratogenic".

Justification for classification or non-classification

Existing in vivo studies of rats exposed to 2-vinylpyridine have been reviewed to ascertain the potential for reproductive toxicity. Concerning fertility, minor effects in the reproductive organs were observed at doses higher than those associated with general toxicity. Concerning teratogenicity, a structure-activity model predicts that 2 -VP is inactive (non-teratogenic).

Using a weight of evidence approach, 2-VP is not considered a reproductive toxicant. Further testing is not appropriate, as this substance is corrosive at the site of contact. Protection of workers against general toxicity will protect against any potential effects on the reproductive tract.

Additional information