2-vinylpyridine

Genetic toxicity: in vivo

Administrative data

Endpoint:

in vivo mammalian cell study: DNA damage and/or repair

Remarks:

Type of genotoxicity: DNA damage and/or repair

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This is a validated SAR model where the substance falls within the applicability domain of the model, as provided in the attached documentation. The results are adequate for the purpose of classification and labeling, and for risk assessment.

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2010

Report date:

2010

Materials and methods

Test guideline

Guideline:

other: SAR prediction of micronucleus activity

Principles of method if other than guideline:

The cat-SAR structure-activity relationship (SAR) program estimates the toxicological properties of chemicals based on information from previously tested compounds and the method has been described in detail in several peer-reviewed publications. The models are built for specific toxicological endpoints and describe chemical substructures that differentiate between active and inactive chemicals for the endpoint of interests (e.g., carcinogens and noncarcinogens). The cat-SAR approach is a qualitative SAR method. Chemicals in the model’s learning set are classified as positive or negative (rather than units of potency). The metric of activity is used to determine the classification based on a defined Cut-Point value that separates positive from negative prediction. The model’s sensitivity, specificity, and concordance are used to judge the likelihood that a prediction is accurate.

GLP compliance:

no

Type of assay:

micronucleus assay

Test material

Test material information

Constituent 1

Reference substance name:

2-vinylpyridine

EC Number:

202-879-8

EC Name:

2-vinylpyridine

Cas Number:

100-69-6

Molecular formula:

C7H7N

IUPAC Name:

2-ethenylpyridine

Test animals

Species:

mouse

Sex:

male/female

Administration / exposure

Route of administration:

other: unspecified

Results and discussion

Test results

Sex:

male/female

Genotoxicity:

negative

Toxicity:

not examined

Negative controls validity:

valid

Positive controls validity:

valid

Any other information on results incl. tables

The substance is predicted to be "inactive", or "non-mutagenic", based on a predicted value (model results) of 0.35 with a cut-point to designate active materials of 0.38.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): negative
2-Vinylpyridine was investigated in a validated SAR model for activity in the mouse micronucleus assay. This substance is similar to compounds which were not active. Thus, 2-vinylpyridine is concluded to be non-mutagen.