Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-981-6 | CAS number: 3687-46-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given in summarized study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Decyl oleate
- EC Number:
- 222-981-6
- EC Name:
- Decyl oleate
- Cas Number:
- 3687-46-5
- Molecular formula:
- C28H54O2
- IUPAC Name:
- decyl octadec-9-enoate
- Details on test material:
- - Name of test material (as cited in study report): Oleate de Decyle S
- Analytical purity: no data given
- Code: 10117
- Lot/batch No.: 0609 G
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Controls:
- other: untreated sites of the same animal served as control
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 5 days
- Number of animals:
- 3 male rabbits
- Details on study design:
- The interpretation of the results was according to 67/548/EEC guideline.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24-48-72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 5 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24-48-72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24-48-72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 5 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24-48-72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 5 days
Any other information on results incl. tables
Table 1: Erythema and edema scores for skin irritation of the individual animals at different reading time points:
Animal No. |
Reading time point |
Erythema score |
Edema score |
1 |
1 h |
1 |
0 |
|
24 h |
1 |
0 |
|
48 h |
1 |
0 |
|
72 h |
1 |
0 |
|
5 d |
0 |
0 |
2 |
1 h |
1 |
0 |
|
24 h |
1 |
0 |
|
48 h |
0 |
0 |
|
72 h |
0 |
0 |
|
5 d |
0 |
0 |
3 |
1 h |
1 |
1 |
|
24 h |
2 |
1 |
|
48 h |
1 |
1 |
|
72 h |
1 |
1 |
|
5 d |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Under the experimental condititons of the study, the test material does not fulfill the requirements to be classified according to EU- (67/548 EEC) or GHS- (1272/2008 EC) criteria. Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
